Phenotypes Associated with This Genotype

Genotype
MGI:5430804

• Allelic Composition: Adgrl3^{Gt(S17-5H1)Sor}/Adgrl3^{Gt(S17-5H1)Sor}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:259247 )

N • mice exhibit normal working memory and motor coordination

enhanced behavioral response to cocaine ( J:185872 )

• mice treated with cocaine exhibit increased horizontal activity compared with wild-type mice

abnormal eating behavior ( J:259247 )

• mice exhibit a greater instrumental responding for food indicating an increase in reward motivation

abnormal emotion/affect behavior ( J:259247 )

• mice take a longer time to become immobile within the first 2 min of the forced swim test and spend less time immobile in the last 4 min

decreased anxiety-related response ( J:185872 )

• mice spend more time in the center of an open field than wild-type mice

hyperactivity ( J:185872 )

• increased horizontal activity in an open field

increased locomotor activity ( J:259247 )

• mice swim incessantly during a forced swim assay indicating an increase in activity levels

induced hyperactivity ( J:185872 )

• mice treated with cocaine exhibit increased horizontal activity compared with wild-type mice

increased stereotypic behavior ( J:185872 )

nervous system

abnormal neurite morphology ( J:259247 )

• primary cortical neurons show enhanced neurite outgrowth in culture with increased length and branching

homeostasis/metabolism

decreased circulating calcium level ( J:259247 )

• low serum calcium levels

• however, vitamin D3 levels are normal

increased dopamine level ( J:185872 )

• in the dorsal striatum

increased serotonin level ( J:185872 )

• in the dorsal striatum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:259247