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Arhgef11 Gene Detail
Summary
  • Symbol
    Arhgef11
  • Name
    Rho guanine nucleotide exchange factor (GEF) 11
  • Synonyms
    PDZ-RhoGEF, Prg
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441869
    NCBI Gene: 213498
  • Gene Overview
    MyGene.info: ARHGEF11
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:87617559-87738034 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      120476 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.22 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ARHGEF11, Rho guanine nucleotide exchange factor 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGEF11, Rho guanine nucleotide exchange factor 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GTRAP48, PDZ-RHOGEF
  • Links
    NCBI Gene ID: 9826
    neXtProt AC: NX_O15085
    UniProt: O15085

  • Chr Location
    1q23.1; chr1:156934840-157046903 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    2 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit no obvious phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031939 VEGA Gene Model | MGI Sequence Detail 120476 C57BL/6J ±  kb
    transcript OTTMUST00000079227 VEGA | MGI Sequence Detail 6776 Not Applicable  
    polypeptide OTTMUSP00000042231 VEGA | MGI Sequence Detail 1552 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      853 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR000219 Dbl homology (DH) domain
      IPR035899 Dbl homology (DH) domain superfamily
      IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
      IPR001478 PDZ domain
      IPR036034 PDZ superfamily
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR015212 Regulator of G protein signalling-like domain
      IPR016137 RGS domain
      IPR036305 RGS domain superfamily
      IPR032919 Rho guanine nucleotide exchange factor 11
      IPR037803 Rho guanine nucleotide exchange factor 11, PH domain
      IPR037889 Rho guanine nucleotide exchange factor 11, RGS domain
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 2
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:245876 Rohacek AM, et al., ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Dev Cell. 2017 Nov 06;43(3):318-331.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory