Dclre1c
Gene Detail

Symbol Name ID

Dclre1c DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) MGI:2441769

Synonyms

9930121L06Rik, Art, Artemis

Feature Type

protein coding gene

Genetic Map

Chromosome 2

1.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:3424131-3464130 bp, + strand From VEGA annotation of GRCm38   40000 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32547  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dclre1c

Human homologs

Human Homolog		DCLRE1C, DNA cross-link repair 1C
NCBI Gene ID		64421
neXtProt AC		NX_Q96SD1
Human Synonyms		A-SCID, DCLREC1C, hSNM1C, RS-SCID, SCIDA, SNM1C
Human Chr (Location)		10p13; chr10:14948870-14996094 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human DCLRE1C

Alleles and phenotypes

All alleles(8) : Targeted(7) Gene trapped(1)
 

Homozygous mutant mice exhibit a combined immunodeficiency phenotype. While immunoglobulin rearrangement is completely blocked in B cells, the block of V(D)J rearrangement in T cells is partial.

 
Human Diseases Modeled Using Mouse Dclre1c (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	B cell differentiation, chromosome organization, ...
Component	nucleus
Function	5'-3' exonuclease activity, endonuclease activity, ...

External Resources: FuncBase

Expression

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(10)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000010775 (Evidence)
Ensembl Gene Model	ENSMUSG00000026648 (Evidence)
Entrez Gene	227525 (Evidence)
EC	3.1.-.-
Consensus CDS Project	CCDS15649.1, CCDS15650.1, CCDS50486.1
International Mouse Knockout Project Status	Dclre1c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010775	VEGA Gene Model | MGI Sequence Detail	40000	C57BL/6J
transcript	OTTMUST00000025191	VEGA | MGI Sequence Detail	2469	Not Applicable
polypeptide	OTTMUSP00000011552	VEGA | MGI Sequence Detail	705	Not Applicable

All sequences(51) RefSeq(6) UniProt(4)

Polymorphisms

SNPs(184 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001279	Beta-lactamase-like
InterPro	IPR011084	DNA repair metallo-beta-lactamase
Protein Ontology	PR:000006315	protein artemis

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:194422 Vera G, et al., Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans. Mol Cell Biol. 2013 Feb;33(4):701-11
All references(48)

Other accession IDs

MGI:2139032