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Gpr68 Gene Detail
Summary
  • Symbol
    Gpr68
  • Name
    G protein-coupled receptor 68
  • Synonyms
    OGR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441763
    NCBI Gene: 238377
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:100842941-100874457 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 51.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441763
 protein coding gene Chr12:100842941-100874457 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020021
 protein coding gene Chr12:102363742-102398412 (-)
A/J MGP_AJ_G0019976
 protein coding gene Chr12:98509777-98541278 (-)
AKR/J MGP_AKRJ_G0019952
 protein coding gene Chr12:101201123-101234235 (-)
BALB/cJ MGP_BALBcJ_G0019962
 protein coding gene Chr12:98862167-98894452 (-)
C3H/HeJ MGP_C3HHeJ_G0019764
 protein coding gene Chr12:101731157-101764336 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020411
 protein coding gene Chr12:105536034-105568649 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018025
 protein coding gene Chr12:95489621-95521834 (-)
CAST/EiJ MGP_CASTEiJ_G0019310
 protein coding gene Chr12:96842508-96876405 (-)
CBA/J MGP_CBAJ_G0019736
 protein coding gene Chr12:109429155-109470299 (-)
DBA/2J MGP_DBA2J_G0019847
 protein coding gene Chr12:97961754-97993693 (-)
FVB/NJ MGP_FVBNJ_G0019836
 protein coding gene Chr12:96681789-96713404 (-)
LP/J MGP_LPJ_G0019923
 protein coding gene Chr12:102218726-102252535 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019878
 protein coding gene Chr12:113019338-113053731 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020440
 protein coding gene Chr12:100771495-100805201 (-)
PWK/PhJ MGP_PWKPhJ_G0019074
 protein coding gene Chr12:92601535-92634097 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018870
 protein coding gene Chr12:94958216-94989912 (-)
WSB/EiJ MGP_WSBEiJ_G0019364
 protein coding gene Chr12:101634991-101669048 (-)



Homology
more
  • Human Ortholog
    GPR68, G protein-coupled receptor 68
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR68, G protein-coupled receptor 68
  • Synonyms
    AI2A6, GPR12A, OGR1
  • Links
    NCBI Gene ID: 8111
    neXtProt AC: NX_Q15743
    UniProt: Q15743

  • Chr Location
    14q32.11; chr14:91232532-91270790 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GPR68 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 5 alleles in 6 genetic backgrounds
    3 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased osteoclastogenesis, abnormal pH-sensitive osteoclast survival, and background sensitive alterations in brown adipose tissue, monocytes, and macrophages. Mice homozygous for a different allele exhibit attenuated glucose-stimulated insulin secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    56
  • cDNA Data
    11
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 238377 NCBI Gene Model | MGI Sequence Detail 31517 C57BL/6J ±  kb
    transcript NM_001403314 RefSeq | MGI Sequence Detail 3448 C57BL/6  
    polypeptide Q8BFQ3 UniProt | EBI | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145071
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 26
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:332522 Shore D, et al., GPR68 limits the severity of chemical-induced oral epithelial dysplasia. Sci Rep. 2023 Jan 7;13(1):353
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory