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Tbl1xr1 Gene Detail
Summary
  • Symbol
    Tbl1xr1
  • Name
    transducin (beta)-like 1X-linked receptor 1
  • Synonyms
    8030499H02Rik, A630076E03Rik, C21, C230089I12Rik, DC42, Ira1, TBLR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441730
    NCBI Gene: 81004
  • Gene Overview
    MyGene.info: TBL1XR1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:22076652-22216594 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 7.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    498 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441730
protein coding gene Chr3:22076592-22216594 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027104
protein coding gene Chr3:19340842-19487469 (+)
A/J MGP_AJ_G0027064
protein coding gene Chr3:19232903-19375057 (+)
AKR/J MGP_AKRJ_G0027033
protein coding gene Chr3:19438594-19580386 (+)
BALB/cJ MGP_BALBcJ_G0027076
protein coding gene Chr3:18910897-19053011 (+)
C3H/HeJ MGP_C3HHeJ_G0026817
protein coding gene Chr3:19428929-19577680 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027521
protein coding gene Chr3:20469052-20620351 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024883
protein coding gene Chr3:17762250-17915099 (+)
CAST/EiJ MGP_CASTEiJ_G0026272
protein coding gene Chr3:19303607-19456891 (+)
CBA/J MGP_CBAJ_G0026795
protein coding gene Chr3:20999067-21157839 (+)
DBA/2J MGP_DBA2J_G0026929
protein coding gene Chr3:18799176-18939776 (+)
FVB/NJ MGP_FVBNJ_G0026897
protein coding gene Chr3:18403727-18544289 (+)
LP/J MGP_LPJ_G0027041
protein coding gene Chr3:19948270-20097080 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026918
protein coding gene Chr3:23079664-23230877 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027581
protein coding gene Chr3:19176941-19323675 (+)
PWK/PhJ MGP_PWKPhJ_G0026005
protein coding gene Chr3:18467374-18611387 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025814
protein coding gene Chr3:18884046-19026286 (+)
WSB/EiJ MGP_WSBEiJ_G0026345
protein coding gene Chr3:19186760-19333310 (+)



Homology
more
  • Human Ortholog
    TBL1XR1, transducin beta like 1 X-linked receptor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TBL1XR1, transducin beta like 1 X-linked receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C21, DC42, IRA1, MRD41, TBLR1
  • Links
    NCBI Gene ID: 79718
    neXtProt AC: NX_Q9BZK7
    UniProt: Q9BZK7

  • Chr Location
    3q26.32; chr3:177019355-177197357 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TBL1XR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in adipose tissue exhibit increased body weight, and total body fat and increased susceptibility to diet-induced obesity and impaired glucose homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027630 Ensembl Gene Model | MGI Sequence Detail 139943 C57BL/6J ±  kb
    transcript ENSMUST00000193734 Ensembl | MGI Sequence Detail 8237 Not Applicable  
    polypeptide ENSMUSP00000142184 Ensembl | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2139993, MGI:2444715
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:261297 Moretti C, et al., SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation. Cell Death Differ. 2017 Jun;24(6):1029-1044

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory