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Sctr
Gene Detail
Symbol

Name
ID
Sctr
secretin receptor
MGI:2441720
Synonyms
6530402O03Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
52.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:120006894-120063536 bp, + strand
From VEGA annotation of GRCm38

  56643 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68290  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Sctr

Human
homologs
Human Homolog SCTR, secretin receptor
NCBI Gene ID 6344
neXtProt AC  NX_P47872
Human Synonyms  SR
Human Chr (Location)  2q14.1; chr2:119439843-119524452 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Spontaneous(1) Targeted(1)
Genomic Mutations involving Sctr (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit mild polydipsia, decreased urine osmolality, polyuria, higher serum glucose levels, altered glomerular and tubular morphology, impaired renal water reabsorption, and abnormal water intake in response to secretin or angiotensin II treatment.
 
Interactions
Sctr interacts with 38 markers (Mir15a, Mir128-1, Mir128-2, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) Genomic(1) cDNA(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000049072 (Evidence)
Ensembl Gene ModelENSMUSG00000026387 (Evidence)
Entrez Gene319229 (Evidence)
UniGene189223
DFCITC1621462, TC1592169
DoTSDT.101724435, DT.94272798
NIA Mouse Gene IndexU000725
Consensus CDS ProjectCCDS48341.1
International Mouse Knockout Project StatusSctr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049072 VEGA Gene Model | MGI Sequence Detail 56643 C57BL/6J ±  kb
transcript OTTMUST00000125325 VEGA | MGI Sequence Detail 2012 Not Applicable 
polypeptide OTTMUSP00000067979 VEGA | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(18) UniProt(3)
Polymorphisms
SNPs within 2kb(402 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
InterPro IPR002144 GPCR, family 2, secretin receptor
Protein Ontology PR:000014544 secretin receptor
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:208291 Sekar R, et al., Lipolytic actions of secretin in mouse adipocytes. J Lipid Res. 2014 Feb;55(2):190-200
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory