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Sctr
Gene Detail
 Symbol
Name
ID
Sctr
secretin receptor
MGI:2441720
Synonyms 6530402O03Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
52.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:120006980-120063528 bp, + strand
From Ensembl annotation of GRCm38

  56549 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68290  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Sctr

Human
homologs
Human Homolog SCTR, secretin receptor
NCBI Gene ID 6344
neXtProt AC  NX_P47872
Human Synonyms  SR
Human Chr (Location)  2q14.1; chr2:119439843-119524452 (-)  GRCh38
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit mild polydipsia, decreased urine osmolality, polyuria, higher serum glucose levels, altered glomerular and tubular morphology, impaired renal water reabsorption, and abnormal water intake in response to secretin or angiotensin II treatment.
 
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell surface receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component cytoplasmic microtubule, integral component of membrane, ...
Function G-protein coupled receptor activity, peptide binding, ...
External Resources: FuncBase
Expression
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(6) Genomic(1) cDNA(5)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026387 (Evidence)
Entrez Gene319229 (Evidence)
UniGene189223
DFCITC1592169, TC1621462
DoTSDT.101724435, DT.94272798
NIA Mouse Gene IndexU000725
Consensus CDS ProjectCCDS48341.1
International Mouse Knockout Project StatusSctr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026387 Ensembl Gene Model | MGI Sequence Detail 56549 C57BL/6J ±  kb
transcript ENSMUST00000072886 Ensembl | MGI Sequence Detail 1918 Not Applicable 
polypeptide ENSMUSP00000072660 Ensembl | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(18) UniProt(2)
Polymorphisms SNPs within 2kb(402 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
InterPro IPR002144 GPCR, family 2, secretin receptor
Protein Ontology PR:000014544 secretin receptor
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:208291 Sekar R, et al., Lipolytic actions of secretin in mouse adipocytes. J Lipid Res. 2014 Feb;55(2):190-200
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory