Sctr
Gene Detail

Symbol Name ID

Sctr secretin receptor MGI:2441720

Synonyms

6530402O03Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

52.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:120006980-120063528 bp, + strand From Ensembl annotation of GRCm38   56549 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68290  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Sctr

Human homologs

Human Homolog		SCTR, secretin receptor
NCBI Gene ID		6344
neXtProt AC		NX_P47872
Human Synonyms		SR
Human Chr (Location)		2q14.1; chr2:120197419-120282028 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a knock-out allele exhibit mild polydipsia, decreased urine osmolality, polyuria, higher serum glucose levels, altered glomerular and tubular morphology, impaired renal water reabsorption, and abnormal water intake in response to secretin or angiotensin II treatment.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	cell surface receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component	cytoplasmic microtubule, integral to membrane, ...
Function	G-protein coupled receptor activity, peptide binding, ...

External Resources: FuncBase

Expression

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) Genomic(1) cDNA(6)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000026387 (Evidence)
Entrez Gene	319229 (Evidence)
UniGene	189223
DFCI	TC1592169, TC1621462
DoTS	DT.101724435, DT.94272798
NIA Mouse Gene Index	U000725
Consensus CDS Project	CCDS48341.1
International Mouse Knockout Project Status	Sctr

Sequences

Length	Strain/Species
genomic	ENSMUSG00000026387	Ensembl Gene Model | MGI Sequence Detail	56549	C57BL/6J
transcript	ENSMUST00000072886	Ensembl | MGI Sequence Detail	1918	Not Applicable
polypeptide	ENSMUSP00000072660	Ensembl | MGI Sequence Detail	464	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(207 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
InterPro	IPR002144	GPCR, family 2, secretin receptor
Protein Ontology	PR:000014544	secretin receptor

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(26)