About   Help   FAQ
Sctr Gene Detail
Summary
  • Symbol
    Sctr
  • Name
    secretin receptor
  • Synonyms
    6530402O03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441720
    NCBI Gene: 319229
  • Gene Overview
    MyGene.info: SCTR
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:120006899-120063539 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441720
protein coding gene Chr1:120006894-120063539 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016401
protein coding gene Chr1:122777496-122844975 (+)
A/J MGP_AJ_G0016384
protein coding gene Chr1:118380952-118437685 (+)
AKR/J MGP_AKRJ_G0016349
protein coding gene Chr1:121865550-121923292 (+)
BALB/cJ MGP_BALBcJ_G0016344
protein coding gene Chr1:118644148-118702776 (+)
C3H/HeJ MGP_C3HHeJ_G0016170
protein coding gene Chr1:122034455-122097477 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016805
protein coding gene Chr1:127461579-127524408 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014518
protein coding gene Chr1:112036176-112087723 (+)
CAST/EiJ MGP_CASTEiJ_G0015751
protein coding gene Chr1:120824290-120888801 (+)
CBA/J MGP_CBAJ_G0016143
protein coding gene Chr1:131872839-131942122 (+)
DBA/2J MGP_DBA2J_G0016249
protein coding gene Chr1:117404020-117464359 (+)
FVB/NJ MGP_FVBNJ_G0016248
protein coding gene Chr1:116154394-116212783 (+)
LP/J MGP_LPJ_G0016320
protein coding gene Chr1:124129019-124194800 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016273
protein coding gene Chr1:137612187-137688713 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016841
protein coding gene Chr1:121592614-121654182 (+)
PWK/PhJ MGP_PWKPhJ_G0015537
protein coding gene Chr1:116383199-116442727 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015325
protein coding gene Chr1:120478197-120538401 (+)
WSB/EiJ MGP_WSBEiJ_G0015813
protein coding gene Chr1:121465789-121527265 (+)



Homology
more
  • Human Ortholog
    SCTR, secretin receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SCTR, secretin receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SR
  • Links
    NCBI Gene ID: 6344
    neXtProt AC: NX_P47872
    UniProt: P47872

  • Chr Location
    2q14.2; chr2:119439843-119524452 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show polydipsia, polyuria, decreased urine osmolality, higher serum glucose levels, kidney glomerular and tubular pathology, and impaired renal water reabsorption. Homozygotes for a different null allele show impaired synaptic plasticity and social behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 319229 NCBI Gene Model | MGI Sequence Detail 56641 C57BL/6J ±  kb
transcript NM_001012322 RefSeq | MGI Sequence Detail 1939 C57BL/6  
polypeptide Q5FWI2 UniProt | EBI | MGI Sequence Detail 447 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001879 GPCR, family 2, extracellular hormone receptor domain
    IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
    IPR017981 GPCR, family 2-like
    IPR000832 GPCR, family 2, secretin-like
    IPR017983 GPCR, family 2, secretin-like, conserved site
    IPR002144 GPCR, family 2, secretin receptor
Molecular
Reagents
less
  • All nucleic 7
    Genomic 2
    cDNA 5

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Diseases 1
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:266334 Wu N, et al., The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor-beta1-Mediated Biliary Senescence. Am J Pathol. 2018 Oct;188(10):2264-2280

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory