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Sctr
Gene Detail
Symbol

Name
ID
Sctr
secretin receptor
MGI:2441720
Synonyms
6530402O03Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
52.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:120006894-120063536 bp, + strand
From VEGA annotation of GRCm38

  56643 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68290  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SCTR
Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Sctr

Human
homologs
SCTR, secretin receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6344
neXtProt AC: NX_P47872

Human Synonyms: SR

Human Chr (Location): 2q14.1; chr2:119439843-119524452 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Spontaneous(1) Targeted(1)
Genomic Mutations involving Sctr (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit mild polydipsia, decreased urine osmolality, polyuria, higher serum glucose levels, altered glomerular and tubular morphology, impaired renal water reabsorption, and abnormal water intake in response to secretin or angiotensin II treatment.
 
Interactions
Sctr interacts with 37 markers (Mir15a, Mir128-1, Mir128-2, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) Genomic(1) cDNA(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000049072 (Evidence)
Ensembl Gene Model ENSMUSG00000026387 (Evidence)
Entrez Gene 319229 (Evidence)
UniGene 189223
DFCI TC1592169, TC1621462
DoTS DT.101724435, DT.94272798
NIA Mouse Gene Index U000725
Consensus CDS Project CCDS48341.1, CCDS78668.1
International Mouse Phenotyping Consortium Status Sctr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049072 VEGA Gene Model | MGI Sequence Detail 56643 C57BL/6J ±  kb
transcript OTTMUST00000125325 VEGA | MGI Sequence Detail 2012 Not Applicable 
polypeptide OTTMUSP00000067979 VEGA | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(24) UniProt(2)
Polymorphisms
SNPs within 2kb(402 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
InterPro IPR002144 GPCR, family 2, secretin receptor
Protein Ontology PR:000014544 secretin receptor
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:216627 Sekar R, et al., Secretin receptor-knockout mice are resistant to high-fat diet-induced obesity and exhibit impaired intestinal lipid absorption. FASEB J. 2014 Aug;28(8):3494-505
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory