Mcat
Gene Detail

Symbol Name ID

Mcat malonyl CoA:ACP acyltransferase (mitochondrial) MGI:2388651

Feature Type

protein coding gene

Genetic Map

Chromosome 15

39.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:83546797-83555711 bp, - strand From NCBI annotation of GRCm38   8915 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15511  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mcat

Human homologs

Human Homolog		MCAT, malonyl CoA:ACP acyltransferase (mitochondrial)
NCBI Gene ID		27349
neXtProt AC		NX_Q8IVS2
Human Synonyms		fabD, FASN2C, MCT, MT, NET62
Human Chr (Location)		22q13.31; chr22:43528212-43539403 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for a conditional allele activated ubiquitously consume more food, fail to gain weight, are less physically active, and suffer from loss of white adipose tissue, reduced muscle strength, kyphosis, alopecia, hypothermia and shortened lifespan.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	fatty acid biosynthetic process, fatty acid metabolic process, ...
Component	mitochondrion
Function	[acyl-carrier-protein] S-malonyltransferase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(1) cDNA(30)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000048755 (Evidence)
Entrez Gene	223722 (Evidence)
UniGene	37560
DFCI	TC1579693
DoTS	DT.40158226, DT.485055
NIA Mouse Gene Index	U036478
EC	2.3.1.39
Consensus CDS Project	CCDS27704.1
International Mouse Knockout Project Status	Mcat

Sequences

Length	Strain/Species
genomic	223722	NCBI Gene Model | MGI Sequence Detail	8915	C57BL/6J
transcript	NM_001030014	RefSeq | MGI Sequence Detail	1893	C57BL/6
polypeptide	Q8R3F5	UniProt | EBI | MGI Sequence Detail	381	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014043	Acyl transferase
InterPro	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
InterPro	IPR001227	Acyl transferase domain
InterPro	IPR016036	Malonyl-CoA ACP transacylase, ACP-binding
Protein Ontology	PR:000010231	malonyl-CoA-acyl carrier protein transacylase, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:192213 Smith S, et al., Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. PLoS One. 2012;7(10):e47196
All references(35)

Other accession IDs

MGI:2145961