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Mcat Gene Detail
Summary
  • Symbol
    Mcat
  • Name
    malonyl CoA:ACP acyltransferase (mitochondrial)
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388651
    NCBI Gene: 223722
  • Gene Overview
    MyGene.info: MCAT
Location & Maps
more
  • Sequence Map
    Chr15:83546797-83555711 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8915 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 39.40 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MCAT, malonyl-CoA-acyl carrier protein transacylase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCAT, malonyl-CoA-acyl carrier protein transacylase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    fabD, FASN2C, MCT, MT, NET62
  • Links
    NCBI Gene ID: 27349
    neXtProt AC: NX_Q8IVS2

  • Chr Location
    22q13.31; chr22:43132206-43143397 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 15511
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MCAT
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 1 allele in 2 genetic backgrounds
    3 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Mcat
  • Incidental Mutations
Mice homozygous for a conditional allele activated ubiquitously consume more food, fail to gain weight, are less physically active, and suffer from loss of white adipose tissue, reduced muscle strength, kyphosis, alopecia, hypothermia and shortened lifespan.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048755 Ensembl Gene Model | MGI Sequence Detail 8915 C57BL/6J ±  kb
transcript ENSMUST00000061882 Ensembl | MGI Sequence Detail 1893 Not Applicable  
polypeptide ENSMUSP00000051569 Ensembl | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    146 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010231 malonyl-CoA-acyl carrier protein transacylase, mitochondrial
  • EC
  • InterPro Domains
    IPR014043 Acyl transferase
    IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
    IPR001227 Acyl transferase domain
    IPR016036 Malonyl-CoA ACP transacylase, ACP-binding
    IPR020801 Polyketide synthase, acyl transferase domain
Molecular
Reagents
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  • All nucleic 31
    Genomic 1
    cDNA 30

    Microarray probesets 2
Other
Accession IDs
less
MGI:2145961
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 23
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:192213 Smith S, et al., Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. PLoS One. 2012;7(10):e47196

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory