Tmem63b MGI Mouse Gene Detail - MGI:2387609

Tmem63b Gene Detail

Symbol

Tmem63b
Name

transmembrane protein 63b

Feature Type

protein coding gene
IDs

MGI:2387609
NCBI Gene: 224807
Alliance

gene page

Sequence Map

Chr17:45660171-45686905 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

26735 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 22.59 cM
Mapping Data

1 experiment

Human Ortholog

TMEM63B, transmembrane protein 63B

Vertebrate Orthologs

9

Human Ortholog

TMEM63B, transmembrane protein 63B
Orthology source: HomoloGene, HGNC
Synonyms

C6orf110
Links

HGNC:17735

NCBI Gene ID: 55362

neXtProt AC: NX_Q5T3F8

UniProt: Q5T3F8
Chr Location

6p21.1; chr6:44126628-44155519 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 101682
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: TMEM63B
Gene Tree

Tmem63b

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Gene trapped

13
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

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All GO Annotations

6
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

104
Tissues

16
cDNA Data

111
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Tmem63b interacts with 151 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

65
RefSeq

13
UniProt

6
CCDS

CCDS28814.1
UniGene

157904

			Length	Strain/Species	Flank
genomic	OTTMUSG00000031349	VEGA Gene Model \| MGI Sequence Detail	26735	C57BL/6J	± kb
transcript	OTTMUST00000077661	VEGA \| MGI Sequence Detail	3284	Not Applicable
polypeptide	OTTMUSP00000041124	VEGA \| MGI Sequence Detail	832	Not Applicable

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SNPs within 2kb

116 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000032717 CSC1-like protein 2

(term hierarchy)
InterPro Domains

IPR027815 10TM putative phosphate transporter, cytosolic domain

IPR003864 Calcium-dependent channel, 7TM region, putative phosphate

IPR032880 Calcium permeable stress-gated cation channel 1, N-terminal transmembrane domain

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All nucleic 111

cDNA 111

Microarray probesets 3

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 10
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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