Sequence Detail

ID/Version

Q3TWI9 Q6PCL2 Q8C1V5 Q6PGA4 Q8R0W7 (UniProt | EBI)

Last sequence update: 2005-10-11
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Mechanosensitive cation channel TMEM63B {ECO:0000305};AltName: Full=Transmembrane protein 63B; Short=mTMEM63B {ECO:0000303|PubMed:39424995};

Provider

SWISS-PROT

Sequence

Polypeptide 832 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tmem63b	transmembrane protein 63b	57	97	4	20

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:281192 Murthy SE, et al., OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels. Elife. 2018 Nov 1;7:e41844
J:281241 Marques MC, et al., Overexpression of Osmosensitive Ca(2+)-Permeable Channel TMEM63B Promotes Migration in HEK293T Cells. Biochemistry. 2019 Jul 2;58(26):2861-2866
J:281455 Zhao X, et al., Co-expression of mouse TMEM63A, TMEM63B and TMEM63C confers hyperosmolarity activated ion currents in HEK293 cells. Cell Biochem Funct. 2016 Jun;34(4):238-41
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:300916 Wu D, et al., Distant coupling between RNA editing and alternative splicing of the osmosensitive cation channel Tmem63b. J Biol Chem. 2020 Dec 25;295(52):18199-18212
J:303483 Du H, et al., The Cation Channel TMEM63B Is an Osmosensor Required for Hearing. Cell Rep. 2020 May 5;31(5):107596
J:343114 Zheng W, et al., TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels. Neuron. 2023 Jul 28;
J:344717 Qin Y, et al., Cryo-EM structure of TMEM63C suggests it functions as a monomer. Nat Commun. 2023 Nov 9;14(1):7265
J:346997 Chen GL, et al., Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation-induced surfactant secretion. J Clin Invest. 2024 Dec 21;134(5):e174508
J:362023 Tu JJ, et al., The TMEM63B Channel Facilitates Intestinal Motility and Enhances Proliferation of Intestinal Stem Cells. Cells. 2024 Oct 28;13(21)
J:362045 Yang G, et al., TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons. Cell Discov. 2024 Jan 3;10(1):1
J:362047 Niu H, et al., Phospholipid scrambling induced by an ion channel/metabolite transporter complex. Nat Commun. 2024 Aug 31;15(1):7566
J:362049 Miyata Y, et al., Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution. Nat Struct Mol Biol. 2025 Jan;32(1):185-198
J:367055 Wu D, et al., A splicing-dependent ER retention signal regulates surface expression of the mechanosensitive TMEM63B cation channel. J Biol Chem. 2023 Jan;299(1):102781