Tenc1
Gene Detail

Symbol Name ID

Tenc1 tensin like C1 domain-containing phosphatase MGI:2387586

Synonyms

nep, nph, tensin 2

Feature Type

protein coding gene

Genetic Map

Chromosome 15

57.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:102102988-102116401 bp, + strand From NCBI annotation of GRCm38   13414 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37077  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Tenc1

Human homologs

Human Homolog		TENC1, tensin like C1 domain containing phosphatase (tensin 2)
NCBI Gene ID		23371
neXtProt AC		NX_Q63HR2
Human Synonyms		C1TEN, C1-TEN, TNS2
Human Chr (Location)		12q13.13; chr12:53440810-53458163 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Spontaneous(1)
 

Affected mice homozygous for a spontaneous deletion show reduced female fertility, increased blood urea nitrogen, low hematocrit, proteinuria, hypoproteinemia, hypercholesterolemia, small kidneys with a yellowish granular surface, glomerular lesions and premature death; some develop systemic edema.

 
Human Diseases Modeled Using Mouse Tenc1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cellular homeostasis, collagen metabolic process, ...
Component	cell junction, focal adhesion, ...
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (113)    Tissues (28)    Images (21)
Theiler Stages: 23

Assay Type	Results
RNA in situ	113

cDNA source data(70)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(70) cDNA(70)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000037003 (Evidence)
Entrez Gene	209039 (Evidence)
UniGene	29389
DFCI	TC1577830, TC1594174, TC1635657
NIA Mouse Gene Index	U016697
EC	3.1.3.-
Consensus CDS Project	CCDS37224.1
International Mouse Knockout Project Status	Tenc1

Sequences

Length	Strain/Species
genomic	209039	NCBI Gene Model | MGI Sequence Detail	13414	C57BL/6J
transcript	NM_153533	RefSeq | MGI Sequence Detail	4707	FVB/N
polypeptide	Q8CGB6	UniProt | EBI | MGI Sequence Detail	1400	Not Applicable

All sequences(26) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR014019	Phosphatase tensin type
InterPro	IPR006020	Phosphotyrosine interaction domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR000980	SH2 domain
InterPro	IPR014020	Tensin phosphatase, C2 domain
InterPro	IPR013625	Tensin phosphotyrosine-binding domain
Protein Ontology	PR:000016232	tensin-like C1 domain-containing phosphatase

Graphical View of Protein Domain Structure

References

(Earliest) J:24620 Ogura A, et al., Development of nephrotic ICGN mice--the origin, reproductive ability, and incidence of glomerulonephritis. Jikken Dobutsu. 1989 Oct;38(4):349-52
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(51)

Other accession IDs

MGI:1096861