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Tns2 Gene Detail
Summary
  • Symbol
    Tns2
  • Name
    tensin 2
  • Synonyms
    nep, nph, Tenc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387586
    NCBI Gene: 209039
  • Gene Overview
    MyGene.info: TNS2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:102102988-102116401 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13414 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.29 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TNS2, tensin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNS2, tensin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1TEN, C1-TEN, TENC1
  • Links
    NCBI Gene ID: 23371
    neXtProt AC: NX_Q63HR2
    UniProt: Q63HR2

  • Chr Location
    12q13.13; chr12:53046980-53064379 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37077
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TNS2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Tns2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Affected mice homozygous for a spontaneous deletion show reduced female fertility, increased blood urea nitrogen, low hematocrit, proteinuria, hypoproteinemia, hypercholesterolemia, small kidneys with a yellowish granular surface, glomerular lesions and premature death; some develop systemic edema.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037003 Ensembl Gene Model | MGI Sequence Detail 13414 C57BL/6J ±  kb
    transcript ENSMUST00000046144 Ensembl | MGI Sequence Detail 4718 Not Applicable  
    polypeptide ENSMUSP00000041087 Ensembl | MGI Sequence Detail 1407 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      36 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 70

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1096861
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 5
      Phenotypes 46
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:244469 Marusugi K, et al., Functional validation of tensin2 SH2-PTB domain by CRISPR/Cas9-mediated genome editing. J Vet Med Sci. 2016 Oct 01;78(9):1413-1420

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory