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Tns2
Gene Detail
Symbol

Name
ID
Tns2
tensin 2
MGI:2387586
Synonyms
nep, nph, Tenc1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:102102988-102116401 bp, + strand
From Ensembl annotation of GRCm38

  13414 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37077  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Tns2

Human
homologs
Human Homolog   TNS2, tensin 2
NCBI Gene ID 23371
neXtProt AC  NX_Q63HR2
Human Synonyms  C1TEN, C1-TEN, TENC1
Human Chr (Location)  12q13.13; chr12:53047026-53064379 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Spontaneous(1) Targeted(2)
Genomic Mutations involving Tns2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Affected mice homozygous for a spontaneous deletion show reduced female fertility, increased blood urea nitrogen, low hematocrit, proteinuria, hypoproteinemia, hypercholesterolemia, small kidneys with a yellowish granular surface, glomerular lesions and premature death; some develop systemic edema.
 
Human Diseases Modeled in Mice Using Tns2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Tns2 interacts with 83 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process cellular homeostasis, collagen metabolic process, ...
Component cell, cell junction, ...
Function 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (113)    Tissues (28)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 113
cDNA source data(70)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) cDNA(70)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000037003 (Evidence)
Entrez Gene209039 (Evidence)
UniGene29389
DFCITC1577830, TC1594174, TC1635657
NIA Mouse Gene IndexU016697
EC3.1.3.-
Consensus CDS ProjectCCDS37224.1
International Mouse Knockout Project StatusTns2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037003 Ensembl Gene Model | MGI Sequence Detail 13414 C57BL/6J ±  kb
transcript ENSMUST00000046144 Ensembl | MGI Sequence Detail 4718 Not Applicable 
polypeptide ENSMUSP00000041087 Ensembl | MGI Sequence Detail 1407 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000980 SH2 domain
InterPro IPR014020 Tensin phosphatase, C2 domain
InterPro IPR013625 Tensin phosphotyrosine-binding domain
Protein Ontology PR:000016232 tensin-like C1 domain-containing phosphatase
References
(Earliest) J:24620 Ogura A, et al., Development of nephrotic ICGN mice--the origin, reproductive ability, and incidence of glomerulonephritis. Jikken Dobutsu. 1989 Oct;38(4):349-52
(Latest) J:216818 Sasaki H, et al., Quantitative trait Loci for resistance to the congenital nephropathy in tensin 2-deficient mice. PLoS One. 2014;9(6):e99602
All references(53)
Disease annotation references (1)
Other
accession IDs
MGI:1096861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory