About   Help   FAQ
Tns2 Gene Detail
Summary
  • Symbol
    Tns2
  • Name
    tensin 2
  • Synonyms
    nep, nph, Tenc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387586
    NCBI Gene: 209039
  • Gene Overview
    MyGene.info: TNS2
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102100413-102116401 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.29 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387586
protein coding gene Chr15:102100373-102116401 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022398
protein coding gene Chr15:104243215-104256628 (+)
A/J MGP_AJ_G0022360
protein coding gene Chr15:100162309-100175921 (+)
AKR/J MGP_AKRJ_G0022335
protein coding gene Chr15:103193521-103206934 (+)
BALB/cJ MGP_BALBcJ_G0022364
protein coding gene Chr15:100205840-100219253 (+)
C3H/HeJ MGP_C3HHeJ_G0022131
protein coding gene Chr15:103264512-103278187 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022813
protein coding gene Chr15:108131489-108144902 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020336
protein coding gene Chr15:95937926-95951608 (+)
CAST/EiJ MGP_CASTEiJ_G0021657
protein coding gene Chr15:104121433-104134861 (+)
CBA/J MGP_CBAJ_G0022100
protein coding gene Chr15:111907723-111921350 (+)
DBA/2J MGP_DBA2J_G0022231
protein coding gene Chr15:99449224-99462637 (+)
FVB/NJ MGP_FVBNJ_G0022207
protein coding gene Chr15:98504793-98518206 (+)
LP/J MGP_LPJ_G0022300
protein coding gene Chr15:104408495-104421908 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022229
protein coding gene Chr15:115508397-115521810 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022825
protein coding gene Chr15:103213315-103226728 (+)
PWK/PhJ MGP_PWKPhJ_G0021397
protein coding gene Chr15:99597843-99611265 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021229
protein coding gene Chr15:103060604-103074003 (+)
WSB/EiJ MGP_WSBEiJ_G0021707
protein coding gene Chr15:103841342-103854984 (+)



Homology
more
  • Human Ortholog
    TNS2, tensin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNS2, tensin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1TEN, C1-TEN, TENC1
  • Links
    NCBI Gene ID: 23371
    neXtProt AC: NX_Q63HR2
    UniProt: Q63HR2

  • Chr Location
    12q13.13; chr12:53046980-53064379 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37077
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TNS2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Tns2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Affected mice homozygous for a spontaneous deletion show reduced female fertility, increased blood urea nitrogen, low hematocrit, proteinuria, hypoproteinemia, hypercholesterolemia, small kidneys with a yellowish granular surface, glomerular lesions and premature death; some develop systemic edema.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037003 Ensembl Gene Model | MGI Sequence Detail 15989 C57BL/6J ±  kb
    transcript ENSMUST00000046144 Ensembl | MGI Sequence Detail 4718 Not Applicable  
    polypeptide ENSMUSP00000041087 Ensembl | MGI Sequence Detail 1407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 71

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1096861
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 5
      Phenotypes 46
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:244469 Marusugi K, et al., Functional validation of tensin2 SH2-PTB domain by CRISPR/Cas9-mediated genome editing. J Vet Med Sci. 2016 Oct 01;78(9):1413-1420

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory