About   Help   FAQ
Tenc1
Gene Detail
 Symbol
Name
ID
Tenc1
tensin like C1 domain-containing phosphatase
MGI:2387586
Synonyms nep, nph, tensin 2
Feature Type protein coding gene
Genetic Map
Chromosome 15
57.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:102102988-102116401 bp, + strand
From NCBI annotation of GRCm38

  13414 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37077  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Tenc1

Human
homologs
Human Homolog TENC1, tensin like C1 domain containing phosphatase (tensin 2)
NCBI Gene ID 23371
neXtProt AC  NX_Q63HR2
Human Synonyms  C1TEN, C1-TEN, TNS2
Human Chr (Location)  12q13.13; chr12:53047026-53064379 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(2) Spontaneous(1)
 
Affected mice homozygous for a spontaneous deletion show reduced female fertility, increased blood urea nitrogen, low hematocrit, proteinuria, hypoproteinemia, hypercholesterolemia, small kidneys with a yellowish granular surface, glomerular lesions and premature death; some develop systemic edema.
 
Human Diseases Modeled Using Mouse Tenc1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cellular homeostasis, collagen metabolic process, ...
Component cell junction, focal adhesion, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (113)    Tissues (28)    Images (21)
Theiler Stages: 23
Assay TypeResults
RNA in situ 113
cDNA source data(70)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(70) cDNA(70)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000037003 (Evidence)
Entrez Gene209039 (Evidence)
UniGene29389
DFCITC1577830, TC1594174, TC1635657
NIA Mouse Gene IndexU016697
EC3.1.3.-
Consensus CDS ProjectCCDS37224.1
International Mouse Knockout Project StatusTenc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 209039 NCBI Gene Model | MGI Sequence Detail 13414 C57BL/6J ±  kb
transcript NM_153533 RefSeq | MGI Sequence Detail 4707 FVB/N 
polypeptide Q8CGB6 UniProt | EBI | MGI Sequence Detail 1400 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(16) UniProt(1)
Polymorphisms SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR014019 Phosphatase tensin type
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000980 SH2 domain
InterPro IPR014020 Tensin phosphatase, C2 domain
InterPro IPR013625 Tensin phosphotyrosine-binding domain
Protein Ontology PR:000016232 tensin-like C1 domain-containing phosphatase
Graphical View of Protein Domain Structure
References (Earliest) J:24620 Ogura A, et al., Development of nephrotic ICGN mice--the origin, reproductive ability, and incidence of glomerulonephritis. Jikken Dobutsu. 1989 Oct;38(4):349-52
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(50)
Other
accession IDs
MGI:1096861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory