Tns2^nph
Spontaneous Allele Detail

Summary

• Symbol: Tns2^nph
• Name: tensin 2; nephrosis
• MGI ID: MGI:2447990
• Synonyms: nep, Tns2^ICGN
• Gene: Tns2 Location: Chr15:102008848-102024836 bp, + strand Genetic Position: Chr15, 57.29 cM
• Alliance: Tns2^nph page

Mutation origin

• Strain of Origin: ICR

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: A phenotypic mutant that arose in an outbred ICR colony at the National Institute of Health (Japan) in 1986. This is the main causative gene producing nephrosis in the ICGN strain. An 8 base pair deletion in exon 18 (NM_001355636.1:c.1546_1553delTCATCCAC GRCm39:chr15:102019657-102019684delTCATCCAC) causes a frameshift and premature stop codon (p.S516Afs*19). Tenc1 expression is significantly decreased in all organs of ICGN animals. (J:108691)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Tns2 Mutation: 116 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Nephrotic Syndrome (J:21656)

References

• Original: J:16284 Kurosawa T, et al., Nephrosis (nep): a new mouse mutation which causes albuminuria and other symptoms of nephrosis. Mouse Genome. 1993;91(4):876-78
• All: 29 reference(s)