Rbm45 MGI Mouse Gene Detail - MGI:2387367 - RNA binding motif protein 45

Symbol

Rbm45
Name

RNA binding motif protein 45
Synonyms

Drb1, Drbp1, G430095G15Rik

Feature Type

protein coding gene
IDs

MGI:2387367
NCBI Gene: 241490
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:76200328-76214112 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 44.94 cM
Mapping Data

1 experiment

SNPs within 2kb

999 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387367	protein coding gene	Chr2:76200304-76214112 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025864	protein coding gene	Chr2:76767106-76780953 (+)
A/J	MGP_AJ_G0025841	protein coding gene	Chr2:73778130-73791976 (+)
AKR/J	MGP_AKRJ_G0025810	protein coding gene	Chr2:75762116-75775905 (+)
BALB/cJ	MGP_BALBcJ_G0025836	protein coding gene	Chr2:73957724-73971571 (+)
C3H/HeJ	MGP_C3HHeJ_G0025596	protein coding gene	Chr2:75975624-75991900 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026283	protein coding gene	Chr2:79038532-79052310 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023686	protein coding gene	Chr2:71183291-71197083 (+)
CAST/EiJ	MGP_CASTEiJ_G0025058	protein coding gene	Chr2:76303684-76317498 (+)
CBA/J	MGP_CBAJ_G0025577	protein coding gene	Chr2:81964940-81978787 (+)
DBA/2J	MGP_DBA2J_G0025708	protein coding gene	Chr2:73370113-73384324 (+)
FVB/NJ	MGP_FVBNJ_G0025670	protein coding gene	Chr2:72742354-72756151 (+)
LP/J	MGP_LPJ_G0025796	protein coding gene	Chr2:76644727-76660190 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025701	protein coding gene	Chr2:83799751-83813545 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026339	protein coding gene	Chr2:75886207-75900048 (+)
PWK/PhJ	MGP_PWKPhJ_G0024801	protein coding gene	Chr2:73326900-73340707 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024607	protein coding gene	Chr2:76129253-76145025 (+)
WSB/EiJ	MGP_WSBEiJ_G0025127	protein coding gene	Chr2:76345779-76359581 (+)

Human Ortholog

RBM45, RNA binding motif protein 45

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBM45, RNA binding motif protein 45
Synonyms

DRB1, RB-1
Links

HGNC:24468

NCBI Gene ID: 129831

UniProt: Q8IUH3
Chr Location

2q31.2; chr2:178112424-178139011 (+) GRCh38

MGI Vertebrate Homology

Rbm45 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RBM45
Gene Tree

Rbm45

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

4
Targeted

4
Genomic Mutations

3 involving Rbm45
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

25
cDNA Data

23
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rbm45

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All Sequences

36
RefSeq

3
UniProt

2
CCDS

CCDS16157.1

Ensembl

ENSMUSG00000042369 (Evidence)
NCBI Gene

241490

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042369	Ensembl Gene Model \| MGI Sequence Detail	13785	C57BL/6J	± kb
transcript	ENSMUST00000046389	Ensembl \| MGI Sequence Detail	1898	Not Applicable
polypeptide	ENSMUSP00000040420	Ensembl \| MGI Sequence Detail	476	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013803 RNA-binding protein 45

(term hierarchy)
InterPro Domains

IPR052462 Glycine-rich RNA-binding

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034203 RBM45, RNA recognition motif 1

IPR034206 RBM45, RNA recognition motif 2

IPR034207 RBM45, RNA recognition motif 3

IPR034208 RBM45, RNA recognition motif 4

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

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All nucleic 26

cDNA 23

Primer pair 2

Other 1

Microarray probesets 1

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MGI:2443869

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 16
Earliest

J:78809 Tamada H, et al., cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein. Biochem Biophys Res Commun. 2002 Sep 13;297(1):96
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rbm45:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18484	Chr2:76200271-76200295 (+)	-45 bp
Tssr18485	Chr2:76200311-76200368 (+)	12 bp
Tssr18486	Chr2:76200375-76200386 (+)	53 bp
Tssr18487	Chr2:76200397-76200404 (+)	73 bp
Tssr541	Chr2:76200679-76200710 (+)	367 bp
Tssr18488	Chr2:76213909-76213920 (+)	13,587 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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