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Ano2
Gene Detail
Symbol

Name
ID
Ano2
anoctamin 2
MGI:2387214
Synonyms
MGC:38715, Tmem16b
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:125690419-126040126 bp, + strand
From VEGA annotation of GRCm38

  349708 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23221  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: ANO2
Gene Tree: Ano2

Human
homologs
ANO2, anoctamin 2, calcium activated chloride channel
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 57101
neXtProt AC: NX_Q9NQ90

Human Synonyms: C12orf3, TMEM16B

Human Chr (Location): 12p13.3; chr12:5560241-5948791 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele lack calcium-activated chloride currents in the main olfactory epithelium and vomeronasal organ but normal olfaction in behavioral tasks.
 
Interactions
Ano2 interacts with 308 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (25)    Tissues (6)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ano2    NEW 
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000033377 (Evidence)
Ensembl Gene Model ENSMUSG00000038115 (Evidence)
Entrez Gene 243634 (Evidence)
UniGene 333398
DFCI TC1588371, TC1590769
DoTS DT.101313254, DT.101722175, DT.99844759
NIA Mouse Gene Index U007425
Consensus CDS Project CCDS39643.2
International Mouse Phenotyping Consortium Status Ano2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033377 VEGA Gene Model | MGI Sequence Detail 349708 C57BL/6J ±  kb
transcript OTTMUST00000083787 VEGA | MGI Sequence Detail 3925 Not Applicable 
polypeptide OTTMUSP00000045064 VEGA | MGI Sequence Detail 1002 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(22) UniProt(8)
Polymorphisms
SNPs within 2kb(2320 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007632 Anoctamin/TMEM 16
Protein Ontology PR:000004057 anoctamin-2
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:212784 Adomaviciene A, et al., Putative pore-loops of TMEM16/anoctamin channels affect channel density in cell membranes. J Physiol. 2013 Jul 15;591(Pt 14):3487-505
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory