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Ano2
Gene Detail
Symbol

Name
ID
Ano2
anoctamin 2
MGI:2387214
Synonyms
MGC:38715, Tmem16b
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:125690419-126040126 bp, + strand
From VEGA annotation of GRCm38

  349708 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23221  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Ano2

Human
homologs
Human Homolog ANO2, anoctamin 2, calcium activated chloride channel
NCBI Gene ID 57101
neXtProt AC  NX_Q9NQ90
Human Synonyms  C12orf3, TMEM16B
Human Chr (Location)  12p13.3; chr12:5562651-5946232 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele lack calcium-activated chloride currents in the main olfactory epithelium and vomeronasal organ but normal olfaction in behavioral tasks.
 
Interactions
Ano2 interacts with 308 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (25)    Tissues (6)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000033377 (Evidence)
Ensembl Gene ModelENSMUSG00000038115 (Evidence)
Entrez Gene243634 (Evidence)
UniGene333398
DFCITC1590769, TC1588371
DoTSDT.99844759, DT.101722175, DT.101313254
NIA Mouse Gene IndexU007425
Consensus CDS ProjectCCDS39643.2
International Mouse Knockout Project StatusAno2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033377 VEGA Gene Model | MGI Sequence Detail 349708 C57BL/6J ±  kb
transcript OTTMUST00000083787 VEGA | MGI Sequence Detail 3925 Not Applicable 
polypeptide OTTMUSP00000045064 VEGA | MGI Sequence Detail 1002 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(12) UniProt(15)
Polymorphisms
SNPs within 2kb(2320 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007632 Anoctamin/TMEM 16
Protein Ontology PR:000004057 anoctamin-2
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:198369 Suzuki J, et al., Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem. 2013 May 10;288(19):13305-16
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory