Ano2
Gene Detail

Symbol Name ID

Ano2 anoctamin 2 MGI:2387214

Synonyms

MGC:38715, Tmem16b

Feature Type

protein coding gene

Genetic Map

Chromosome 6

59.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:125690419-126040126 bp, + strand From VEGA annotation of GRCm38   349708 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23221  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ano2

Human homologs

Human Homolog		ANO2, anoctamin 2
NCBI Gene ID		57101
neXtProt AC		NX_Q9NQ90
Human Synonyms		C12orf3, TMEM16B
Human Chr (Location)		12p13.3; chr12:5671817-6055398 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele lack calcium-activated chloride currents in the main olfactory epithelium and vomeronasal organ but normal olfaction in behavioral tasks.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	chloride transport, ion transmembrane transport, ...
Component	chloride channel complex, integral to membrane, ...
Function	chloride channel activity, intracellular calcium activated chloride channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (25)    Tissues (6)    Images (14)
Theiler Stages: 22, 23, 24

Assay Type	Results
RNA in situ	25

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(8)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000033377 (Evidence)
Ensembl Gene Model	ENSMUSG00000038115 (Evidence)
Entrez Gene	243634 (Evidence)
UniGene	333398
DFCI	TC1588371, TC1590769
DoTS	DT.101313254, DT.101722175, DT.99844759
NIA Mouse Gene Index	U007425
Consensus CDS Project	CCDS39643.2
International Mouse Knockout Project Status	Ano2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033377	VEGA Gene Model | MGI Sequence Detail	349708	C57BL/6J
transcript	OTTMUST00000083787	VEGA | MGI Sequence Detail	3925	Not Applicable
polypeptide	OTTMUSP00000045064	VEGA | MGI Sequence Detail	1002	Not Applicable

All sequences(44) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(1177 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007632	Anoctamin/TMEM 16
Protein Ontology	PR:000004057	anoctamin-2

References

(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:191236 Wang SZ, et al., Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18589-94
All references(35)