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Glis1 Gene Detail
Summary
  • Symbol
    Glis1
  • Name
    GLIS family zinc finger 1
  • Synonyms
    GliH1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386723
    NCBI Gene: 230587
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:107291788-107492258 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 50.18 cM, cytoband C6
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2525 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386723
 protein coding gene Chr4:107283840-107492258 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028540
 protein coding gene Chr4:108128312-108323303 (+)
A/J MGP_AJ_G0028503
 protein coding gene Chr4:104248454-104446120 (+)
AKR/J MGP_AKRJ_G0028450
 protein coding gene Chr4:106820603-107016367 (+)
BALB/cJ MGP_BALBcJ_G0028522
 protein coding gene Chr4:104442268-104635164 (+)
C3H/HeJ MGP_C3HHeJ_G0028236
 protein coding gene Chr4:107556078-107754650 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028962
 protein coding gene Chr4:112009229-112216668 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026253
 protein coding gene Chr4:99529610-99721577 (+)
CAST/EiJ MGP_CASTEiJ_G0027672
 protein coding gene Chr4:105377086-105579752 (+)
CBA/J MGP_CBAJ_G0028205
 protein coding gene Chr4:115657115-115861922 (+)
DBA/2J MGP_DBA2J_G0028353
 protein coding gene Chr4:103871538-104069184 (+)
FVB/NJ MGP_FVBNJ_G0028321
 protein coding gene Chr4:102742096-102934333 (+)
LP/J MGP_LPJ_G0028454
 protein coding gene Chr4:108331285-108531024 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028347
 protein coding gene Chr4:120925725-121128592 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028998
 protein coding gene Chr4:107049058-107249811 (+)
PWK/PhJ MGP_PWKPhJ_G0027398
 protein coding gene Chr4:102119247-102312562 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027222
 protein coding gene Chr4:104434071-104623648 (+)
WSB/EiJ MGP_WSBEiJ_G0027753
 protein coding gene Chr4:107227065-107428443 (+)



Homology
more
  • Human Ortholog
    GLIS1, GLIS family zinc finger 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLIS1, GLIS family zinc finger 1
  • Links
    NCBI Gene ID: 148979
    neXtProt AC: NX_Q8NBF1
    UniProt: Q8NBF1

  • Chr Location
    1p32.3; chr1:53506237-53739164 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    10 phenotype references
Homozygous mice do not exhibit any overt abnormalities, including behavior, kidney or tooth morphology, up to 6 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1009
  • Tissues
    231
  • cDNA Data
    17
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034762 Ensembl Gene Model | MGI Sequence Detail 200471 C57BL/6J ±  kb
transcript ENSMUST00000046005 Ensembl | MGI Sequence Detail 2906 Not Applicable  
polypeptide ENSMUSP00000035650 Ensembl | MGI Sequence Detail 789 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 17
    Primer pair 3
    Other 4

    Microarray probesets 2
References
more
  • Summaries
    All 40
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:75457 Zhang F, et al., Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis. J Biol Chem. 2002 Mar 22;277(12):10139-49
  • Latest
    J:308819 Wang H, et al., RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6. Biochem Biophys Res Commun. 2021 Jun 11;557:323-328
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory