Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including fat cell differentiation; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; heart and pericardium; sensory organ; and skin. Orthologous to human GLIS1 (GLIS family zinc finger 1).