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Abca5
Gene Detail
 Symbol
Name
ID
Abca5
ATP-binding cassette, sub-family A (ABC1), member 5
MGI:2386607
Synonyms ABC13, B930033A02Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
73.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:110269369-110337716 bp, - strand
From VEGA annotation of GRCm38

  68348 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10263  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Abca5

Human
homologs
Human Homolog ABCA5, ATP-binding cassette, sub-family A (ABC1), member 5
NCBI Gene ID 23461
neXtProt AC  NX_Q8WWZ7
Human Synonyms  ABC13, EST90625
Human Chr (Location)  17q24.3; chr17:69244435-69327182 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit exophthalmos, tremors and collapse of the thyroid gland, and develop a dilated cardiomyopathy with large thrombi due to depression of the cardiac function. Severe edema, liver injury and premature death appear to be sensitive to genetic background.
 
Interactions
Abca5 interacts with 334 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cholesterol efflux, high-density lipoprotein particle remodeling, ...
Component endosome, Golgi apparatus, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) cDNA(47)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000003326 (Evidence)
Ensembl Gene ModelENSMUSG00000018800 (Evidence)
Entrez Gene217265 (Evidence)
UniGene41942
DFCITC1581723, TC1603879, TC1677864
DoTSDT.55247635, DT.87043528, DT.94234625, DT.94234626
NIA Mouse Gene IndexU033581
Consensus CDS ProjectCCDS25591.1
International Mouse Knockout Project StatusAbca5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003326 VEGA Gene Model | MGI Sequence Detail 68348 C57BL/6J ±  kb
transcript OTTMUST00000006988 VEGA | MGI Sequence Detail 8231 Not Applicable 
polypeptide OTTMUSP00000003319 VEGA | MGI Sequence Detail 1642 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(391 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR026082 ABC transporter A, ABCA
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003543 ATP-binding cassette sub-family A member 5
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)
Other
accession IDs
MGI:2443908

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory