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Zc3h12a Gene Detail
Summary
  • Symbol
    Zc3h12a
  • Name
    zinc finger CCCH type containing 12A
  • Synonyms
    Mcpip1, MGC:41320
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385891
    NCBI Gene: 230738
  • Gene Overview
    MyGene.info: ZC3H12A
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:125118423-125127840 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 58.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385891
protein coding gene Chr4:125118414-125127881 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028765
protein coding gene Chr4:126707202-126716618 (-)
A/J MGP_AJ_G0028724
protein coding gene Chr4:121724108-121733524 (-)
AKR/J MGP_AKRJ_G0028677
protein coding gene Chr4:125059647-125069089 (-)
BALB/cJ MGP_BALBcJ_G0028747
protein coding gene Chr4:122313181-122322597 (-)
C3H/HeJ MGP_C3HHeJ_G0028461
protein coding gene Chr4:125141152-125150568 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029189
protein coding gene Chr4:131570862-131580279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026462
protein coding gene Chr4:114888938-114898568 (-)
CAST/EiJ MGP_CASTEiJ_G0027894
protein coding gene Chr4:123204232-123223953 (-)
CBA/J MGP_CBAJ_G0028427
protein coding gene Chr4:134847633-134857049 (-)
DBA/2J MGP_DBA2J_G0028576
protein coding gene Chr4:122193829-122203245 (-)
FVB/NJ MGP_FVBNJ_G0028543
protein coding gene Chr4:120827074-120836490 (-)
LP/J MGP_LPJ_G0028677
protein coding gene Chr4:126988219-126997635 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028569
protein coding gene Chr4:139824611-139834027 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029227
protein coding gene Chr4:125412629-125422078 (-)
PWK/PhJ MGP_PWKPhJ_G0027615
protein coding gene Chr4:118619062-118635758 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027441
protein coding gene Chr4:121205743-121215148 (-)
WSB/EiJ MGP_WSBEiJ_G0027974
protein coding gene Chr4:125496432-125505851 (-)



Homology
more
  • Human Ortholog
    ZC3H12A, zinc finger CCCH-type containing 12A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZC3H12A, zinc finger CCCH-type containing 12A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ423B22.1, MCPIP, MCPIP1, MCPIP-1, Reg1
  • Links
    NCBI Gene ID: 80149
    neXtProt AC: NX_Q5D1E8
    UniProt: Q5D1E8

  • Chr Location
    1p34.3; chr1:37474518-37484377 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit splenomegaly, lymphadenopathy, hyperimmunoglobulinemia, increased auto-antibodies, and defective IL6 post-transcriptional regulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042677 Ensembl Gene Model | MGI Sequence Detail 9418 C57BL/6J ±  kb
transcript ENSMUST00000036188 Ensembl | MGI Sequence Detail 2755 Not Applicable  
polypeptide ENSMUSP00000037172 Ensembl | MGI Sequence Detail 596 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 2
References
more
  • Summaries
    All 61
    Gene Ontology 16
    Phenotypes 28
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:255787 Li Y, et al., Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury. Signal Transduct Target Ther. 2017;2:17066

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory