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Zc3h12a Gene Detail
Summary
  • Symbol
    Zc3h12a
  • Name
    zinc finger CCCH type containing 12A
  • Synonyms
    Mcpip1, MGC:41320
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385891
    NCBI Gene: 230738
  • Gene Overview
    MyGene.info: ZC3H12A
Location & Maps
more
  • Sequence Map
    Chr4:125118423-125127840 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9418 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 58.10 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ZC3H12A, zinc finger CCCH-type containing 12A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZC3H12A, zinc finger CCCH-type containing 12A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    dJ423B22.1, MCPIP, MCPIP1
  • Links
    NCBI Gene ID: 80149
    neXtProt AC: NX_Q5D1E8

  • Chr Location
    1p34.3; chr1:37473455-37484377 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    2
  • Gene trapped
    14
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Zc3h12a
  • Incidental Mutations
Mice homozygous for a null allele exhibit splenomegaly, lymphadenopathy, hyperimmunoglobulinemia, increased auto-antibodies, and defective IL6 post-transcriptional regulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009246 VEGA Gene Model | MGI Sequence Detail 9418 C57BL/6J ±  kb
transcript OTTMUST00000020934 VEGA | MGI Sequence Detail 2755 Not Applicable  
polypeptide OTTMUSP00000009594 VEGA | MGI Sequence Detail 596 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    20 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 2
References
more
  • Summaries
    All 47
    Gene Ontology 16
    Phenotypes 20
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:229326 Mino T, et al., Regnase-1 and Roquin regulate inflammatory mRNAs. Oncotarget. 2015 Jul 20;6(20):17869-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory