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Fras1 Gene Detail
Summary
  • Symbol
    Fras1
  • Name
    Fraser extracellular matrix complex subunit 1
  • Synonyms
    bl, E130113P14Rik, mKIAA1500
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385368
    NCBI Gene: 231470
  • Gene Overview
    MyGene.info: FRAS1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:96373955-96784728 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 47.29 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4162 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385368
protein coding gene Chr5:96373819-96784733 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029765
protein coding gene Chr5:97596667-98029888 (+)
A/J MGP_AJ_G0029731
protein coding gene Chr5:94018847-94428692 (+)
AKR/J MGP_AKRJ_G0029677
protein coding gene Chr5:97165014-97586992 (+)
BALB/cJ MGP_BALBcJ_G0029741
protein coding gene Chr5:95031112-95437130 (+)
C3H/HeJ MGP_C3HHeJ_G0029464
protein coding gene Chr5:97485533-97910502 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030196
protein coding gene Chr5:101760564-102194311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027431
protein coding gene Chr5:89414600-89810354 (+)
CAST/EiJ MGP_CASTEiJ_G0028874
protein coding gene Chr5:96064231-96503627 (+)
CBA/J MGP_CBAJ_G0029434
protein coding gene Chr5:105275760-105720761 (+)
DBA/2J MGP_DBA2J_G0029578
protein coding gene Chr5:94235887-94643465 (+)
FVB/NJ MGP_FVBNJ_G0029537
protein coding gene Chr5:93060674-93465737 (+)
LP/J MGP_LPJ_G0029666
protein coding gene Chr5:98258216-98681989 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029566
protein coding gene Chr5:110346045-110787517 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030229
protein coding gene Chr5:96594642-97023117 (+)
PWK/PhJ MGP_PWKPhJ_G0028593
protein coding gene Chr5:92628612-93031607 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028428
protein coding gene Chr5:94233681-94664688 (+)
WSB/EiJ MGP_WSBEiJ_G0028953
protein coding gene Chr5:96907720-97328793 (+)



Homology
more
  • Human Ortholog
    FRAS1, Fraser extracellular matrix complex subunit 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FRAS1, Fraser extracellular matrix complex subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRASRS1
  • Links
    NCBI Gene ID: 80144
    neXtProt AC: NX_Q86XX4
    UniProt: Q86XX4

  • Chr Location
    4q21.21; chr4:78057323-78544269 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Fras1 mouse models; 1 with human FRAS1 associations

Human Disease Mouse Models
      
IDs
View 5 models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 5 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    9 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for mutations at this locus display a significant amount of embryonic lethality due to hemorrhaging of embryonic blisters. Survival is variable on genetic backgrounds. Kidney development is severely affected and syndactyly is common.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034687 Ensembl Gene Model | MGI Sequence Detail 410774 C57BL/6J ±  kb
    transcript ENSMUST00000036019 Ensembl | MGI Sequence Detail 15848 Not Applicable  
    polypeptide ENSMUSP00000043250 Ensembl | MGI Sequence Detail 4010 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 43
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1573, MGI:2442305, MGI:88167
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 24
      Diseases 5
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:262964 Jordan VK, et al., The role of FREM2 and FRAS1 in the development of congenital diaphragmatic hernia. Hum Mol Genet. 2018 Jun 15;27(12):2064-2075

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory