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Gys2
Gene Detail
 Symbol
Name
ID
Gys2
glycogen synthase 2
MGI:2385254
Synonyms glycogen synthase, liver, LGS, MGC:29379
Feature Type protein coding gene
Genetic Map
Chromosome 6
74.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:142422613-142473109 bp, - strand
From VEGA annotation of GRCm38

  50497 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56580  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gys2

Human
homologs
Human Homolog GYS2, glycogen synthase 2 (liver)
NCBI Gene ID 2998
neXtProt AC  NX_P54840
Human Chr (Location)  12p12.2; chr12:21531527-21630788 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GYS2
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a conditional allele knocked out in the liver results in abnormal glycogen homeostasis, altered glucose homeostasis, decreased exercise endurance, and a phenotype similar to patients with glycogen storage disease 0.
 
Human Diseases Modeled Using Mouse Gys2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Gys2 interacts with 54 markers (Mir7-1, Mir10a, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process glycogen biosynthetic process, glycogen metabolic process, ...
Component cell cortex, cortical actin cytoskeleton, ...
Function catalytic activity, glucose binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (102)    Tissues (96)    Images (1)
Theiler Stages: 22, 24, 28
Assay TypeResults
RNA in situ 94
Western blot 2
RT-PCR 6
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023569 (Evidence)
Ensembl Gene ModelENSMUSG00000030244 (Evidence)
Entrez Gene232493 (Evidence)
UniGene275975
DFCITC1584260
DoTSDT.40152873, DT.486708
NIA Mouse Gene IndexU028004
EC2.4.1.11
Consensus CDS ProjectCCDS20683.1
International Mouse Knockout Project StatusGys2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023569 VEGA Gene Model | MGI Sequence Detail 50497 C57BL/6J ±  kb
transcript OTTMUST00000057504 VEGA | MGI Sequence Detail 2657 Not Applicable 
polypeptide OTTMUSP00000027744 VEGA | MGI Sequence Detail 704 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(621 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008631 Glycogen synthase
Protein Ontology PR:000008366 glycogen [starch] synthase, liver
References (Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:208923 von Wilamowitz-Moellendorff A, et al., Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. Diabetes. 2013 Dec;62(12):4070-82
All references(39)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory