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Lzts2 Gene Detail
Summary
  • Symbol
    Lzts2
  • Name
    leucine zipper, putative tumor suppressor 2
  • Synonyms
    MGC:7094, mKIAA1813
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385095
    NCBI Gene: 226154
Location & Maps
more
  • Sequence Map
    Chr19:45015176-45027104 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11929 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 38.20 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LZTS2, leucine zipper, putative tumor suppressor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LZTS2, leucine zipper, putative tumor suppressor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LAPSER1
  • Links
    NCBI Gene ID: 84445
    neXtProt AC: NX_Q9BRK4

  • Chr Location
    10q24; chr10:100997107-101007836 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 15690
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LZTS2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    3 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Gene trapped
    15
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a null mutation display defects in urinary tract development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035342 Ensembl Gene Model | MGI Sequence Detail 11929 C57BL/6J ±  kb
transcript ENSMUST00000039016 Ensembl | MGI Sequence Detail 2825 Not Applicable  
polypeptide ENSMUSP00000045478 Ensembl | MGI Sequence Detail 671 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    20 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000031890 leucine zipper putative tumor suppressor 2
  • InterPro Domains
    IPR028597 Leucine zipper putative tumour suppressor 2
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:196012 Johnson DT, et al., Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development. J Biol Chem. 2013 Feb 8;288(6):3727-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory