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Lzts2
Gene Detail
Symbol

Name
ID
Lzts2
leucine zipper, putative tumor suppressor 2
MGI:2385095
Synonyms
MGC:7094, mKIAA1813
Feature Type
protein coding gene
Genetic Map
Chromosome 19
38.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:45015176-45027104 bp, + strand
From Ensembl annotation of GRCm38

  11929 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15690  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lzts2

Human
homologs
Human Homolog LZTS2, leucine zipper, putative tumor suppressor 2
NCBI Gene ID 84445
neXtProt AC  NX_Q9BRK4
Human Synonyms  LAPSER1
Human Chr (Location)  10q24; chr10:100997107-101007836 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(15) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display defects in urinary tract development.
 
Phenotype Images(3)
Interactions
Lzts2 interacts with 156 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoskeleton, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000035342 (Evidence)
Entrez Gene226154 (Evidence)
NIA Mouse Gene IndexU019497
Consensus CDS ProjectCCDS29855.1
International Mouse Knockout Project StatusLzts2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035342 Ensembl Gene Model | MGI Sequence Detail 11929 C57BL/6J ±  kb
transcript ENSMUST00000179108 Ensembl | MGI Sequence Detail 2781 Not Applicable 
polypeptide ENSMUSP00000137571 Ensembl | MGI Sequence Detail 671 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000031890 leucine zipper putative tumor suppressor 2
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:196012 Johnson DT, et al., Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development. J Biol Chem. 2013 Feb 8;288(6):3727-38
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory