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Plekhh3 Gene Detail
Summary
  • Symbol
    Plekhh3
  • Name
    pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
  • Synonyms
    MGC:27854
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384950
    NCBI Gene: 217198
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101162679-101171351 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 64.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384950
protein coding gene Chr11:101162679-101171378 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019184
protein coding gene Chr11:103990347-103999041 (-)
A/J MGP_AJ_G0019152
protein coding gene Chr11:99624496-99633190 (-)
AKR/J MGP_AKRJ_G0019121
protein coding gene Chr11:102722294-102730970 (-)
BALB/cJ MGP_BALBcJ_G0019126
protein coding gene Chr11:100115720-100124396 (-)
C3H/HeJ MGP_C3HHeJ_G0018935
protein coding gene Chr11:102890547-102899241 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019575
protein coding gene Chr11:107211438-107220114 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017201
protein coding gene Chr11:97043707-97052363 (-)
CAST/EiJ MGP_CASTEiJ_G0018489
protein coding gene Chr11:103882179-103890863 (-)
CBA/J MGP_CBAJ_G0018904
protein coding gene Chr11:111671502-111680178 (-)
DBA/2J MGP_DBA2J_G0019016
protein coding gene Chr11:99155150-99163844 (-)
FVB/NJ MGP_FVBNJ_G0019006
protein coding gene Chr11:98702001-98710695 (-)
LP/J MGP_LPJ_G0019085
protein coding gene Chr11:104537308-104546002 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019037
protein coding gene Chr11:111229198-111237892 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019613
protein coding gene Chr11:103040455-103049145 (-)
PWK/PhJ MGP_PWKPhJ_G0018252
protein coding gene Chr11:100206908-100215612 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018044
protein coding gene Chr11:102785939-102794628 (-)
WSB/EiJ MGP_WSBEiJ_G0018538
protein coding gene Chr11:103041163-103049857 (-)



Homology
more
  • Human Ortholog
    PLEKHH3, pleckstrin homology, MyTH4 and FERM domain containing H3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PLEKHH3, pleckstrin homology, MyTH4 and FERM domain containing H3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 79990
    neXtProt AC: NX_Q7Z736
    UniProt: Q7Z736

  • Chr Location
    17q21.2; chr17:42667914-42677030 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035172 Ensembl Gene Model | MGI Sequence Detail 8673 C57BL/6J ±  kb
transcript ENSMUST00000043397 Ensembl | MGI Sequence Detail 3056 Not Applicable  
polypeptide ENSMUSP00000046044 Ensembl | MGI Sequence Detail 796 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Gene Ontology 1
    Phenotypes 6
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory