Fam222b MGI Mouse Gene Detail - MGI:2384939 - family with sequence similarity 222, member B

Symbol

Fam222b
Name

family with sequence similarity 222, member B
Synonyms

BC017647, MGC:28990

Feature Type

protein coding gene
IDs

MGI:2384939
NCBI Gene: 216971
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:77985486-78047526 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM
Mapping Data

1 experiment

SNPs within 2kb

164 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384939	protein coding gene	Chr11:77985486-78048165 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018763	protein coding gene	Chr11:79069494-79138370 (+)
A/J	MGP_AJ_G0018729	protein coding gene	Chr11:76051643-76115491 (+)
AKR/J	MGP_AKRJ_G0018699	protein coding gene	Chr11:78356358-78419650 (+)
BALB/cJ	MGP_BALBcJ_G0018703	protein coding gene	Chr11:76460454-76524721 (+)
C3H/HeJ	MGP_C3HHeJ_G0018516	protein coding gene	Chr11:78392818-78460870 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019154	protein coding gene	Chr11:81540865-81609206 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016789	protein coding gene	Chr11:73026589-73089460 (+)
CAST/EiJ	MGP_CASTEiJ_G0018070	protein coding gene	Chr11:78831657-78898901 (+)
CBA/J	MGP_CBAJ_G0018486	protein coding gene	Chr11:85096134-85169214 (+)
DBA/2J	MGP_DBA2J_G0018595	protein coding gene	Chr11:75634997-75697532 (+)
FVB/NJ	MGP_FVBNJ_G0018585	protein coding gene	Chr11:75220864-75284756 (+)
LP/J	MGP_LPJ_G0018666	protein coding gene	Chr11:79609817-79674082 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018611	protein coding gene	Chr11:85529117-85594213 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019194	protein coding gene	Chr11:78594339-78663453 (+)
PWK/PhJ	MGP_PWKPhJ_G0017841	protein coding gene	Chr11:76414995-76479331 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017632	protein coding gene	Chr11:78206731-78269821 (+)
WSB/EiJ	MGP_WSBEiJ_G0018123	protein coding gene	Chr11:78413535-78477168 (+)

Human Ortholog

FAM222B, family with sequence similarity 222 member B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM222B, family with sequence similarity 222 member B
Synonyms

C17orf63
Links

HGNC:25563

NCBI Gene ID: 55731

neXtProt AC: NX_Q8WU58

UniProt: Q8WU58
Chr Location

17q11.2; chr17:28755978-28855036 (-) GRCh38.p7

Alliance of Genome Resources

Fam222b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FAM222B
Gene Tree

Fam222b

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Phenotype Summary

16 phenotype references

All Mutations and Alleles

76
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

70
Targeted

4
Genomic Mutations

2 involving Fam222b
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

60 strains or lines available

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

27
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam222b

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Fam222b interacts with 262 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

53
RefSeq

8
UniProt

3
CCDS

CCDS25089.1, CCDS83851.1

Ensembl

ENSMUSG00000037750 (Evidence)
NCBI Gene

216971

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037750	Ensembl Gene Model \| MGI Sequence Detail	62041	C57BL/6J	± kb
transcript	ENSMUST00000073705	Ensembl \| MGI Sequence Detail	3258	Not Applicable
polypeptide	ENSMUSP00000073384	Ensembl \| MGI Sequence Detail	562	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032701 protein FAM222B

(term hierarchy)
InterPro Domains

IPR029340 Protein FAM222

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All nucleic 13

cDNA 13

Microarray probesets 4

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

TSS for Fam222b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103223	Chr11:77985493-77985504 (+)	13 bp
Tssr103224	Chr11:77985508-77985522 (+)	29 bp
Tssr103225	Chr11:77985552-77985563 (+)	72 bp
Tssr103226	Chr11:77991098-77991102 (+)	5,614 bp
Tssr103227	Chr11:78006391-78006427 (+)	20,923 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/22/2022 MGI 6.21