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Rhot2 Gene Detail
Summary
  • Symbol
    Rhot2
  • Name
    ras homolog family member T2
  • Synonyms
    Arht2, Miro2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384892
    NCBI Gene: 214952
  • Gene Overview
    MyGene.info: RHOT2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25838838-25844851 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.93 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384892
protein coding gene Chr17:25838457-25844851 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023376
protein coding gene Chr17:24935790-24942178 (-)
A/J MGP_AJ_G0023335
protein coding gene Chr17:24211358-24217752 (-)
AKR/J MGP_AKRJ_G0023301
protein coding gene Chr17:24316924-24323316 (-)
BALB/cJ MGP_BALBcJ_G0023340
protein coding gene Chr17:24439434-24445822 (-)
C3H/HeJ MGP_C3HHeJ_G0023100
protein coding gene Chr17:24700531-24706921 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023782
protein coding gene Chr17:25988890-25995261 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021258
protein coding gene Chr17:21672889-21679573 (-)
CAST/EiJ MGP_CASTEiJ_G0022602
protein coding gene Chr17:24585874-24592251 (-)
CBA/J MGP_CBAJ_G0023075
protein coding gene Chr17:26900526-26906916 (-)
DBA/2J MGP_DBA2J_G0023205
protein coding gene Chr17:23814034-23820428 (-)
FVB/NJ MGP_FVBNJ_G0023175
protein coding gene Chr17:23554447-23561141 (-)
LP/J MGP_LPJ_G0023282
protein coding gene Chr17:25236447-25242833 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023194
protein coding gene Chr17:26512880-26519272 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023822
protein coding gene Chr17:24636445-24642839 (-)
PWK/PhJ MGP_PWKPhJ_G0022351
protein coding gene Chr17:22575439-22581991 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022169
protein coding gene Chr17:22710214-22716595 (-)
WSB/EiJ MGP_WSBEiJ_G0022665
protein coding gene Chr17:24687147-24693528 (-)



Homology
more
  • Human Ortholog
    RHOT2, ras homolog family member T2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RHOT2, ras homolog family member T2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARHT2, C16orf39, MIRO2, MIRO-2, RASL
  • Links
    NCBI Gene ID: 89941
    neXtProt AC: NX_Q8IXI1
    UniProt: Q8IXI1

  • Chr Location
    16p13.3; chr16:668083-674174 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile with normal mitochondria distribution in neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 214952 NCBI Gene Model | MGI Sequence Detail 6014 C57BL/6J ±  kb
    transcript NM_001364950 RefSeq | MGI Sequence Detail 2867 C57BL/6  
    polypeptide Q8JZN7 UniProt | EBI | MGI Sequence Detail 620 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:86784 Bergstrom DE, et al., Overlapping deletions spanning the proximal two-thirds of the mouse t complex. Mamm Genome. 2003 Dec;14(12):817-29
    • Latest
      J:240500 Lopez-Domenech G, et al., Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites. Cell Rep. 2016 Oct 04;17(2):317-327

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory