Prmt7 MGI Mouse Gene Detail - MGI:2384879 - protein arginine N-methyltransferase 7

Symbol

Prmt7
Name

protein arginine N-methyltransferase 7
Synonyms

4933402B05Rik, MGC:7929

Feature Type

protein coding gene
IDs

MGI:2384879
NCBI Gene: 214572
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:106937686-106978326 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.11 cM
Mapping Data

3 experiments

SNPs within 2kb

156 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384879	protein coding gene	Chr8:106937568-106979426 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034080	protein coding gene	Chr8:108564874-108611693 (+)
A/J	MGP_AJ_G0034061	protein coding gene	Chr8:104220973-104263297 (+)
AKR/J	MGP_AKRJ_G0033987	protein coding gene	Chr8:107240930-107283271 (+)
BALB/cJ	MGP_BALBcJ_G0034054	protein coding gene	Chr8:104402707-104444905 (+)
C3H/HeJ	MGP_C3HHeJ_G0033766	protein coding gene	Chr8:107970287-108014507 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034574	protein coding gene	Chr8:112539920-112587608 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031516	protein coding gene	Chr8:97349405-97392854 (+)
CAST/EiJ	MGP_CASTEiJ_G0033092	protein coding gene	Chr8:107497115-107544681 (+)
CBA/J	MGP_CBAJ_G0033739	protein coding gene	Chr8:116156500-116208731 (+)
DBA/2J	MGP_DBA2J_G0033894	protein coding gene	Chr8:103555101-103597225 (+)
FVB/NJ	MGP_FVBNJ_G0033839	protein coding gene	Chr8:102489018-102530820 (+)
LP/J	MGP_LPJ_G0033985	protein coding gene	Chr8:108770987-108813323 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033883	protein coding gene	Chr8:119340806-119386850 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034592	protein coding gene	Chr8:107199086-107240881 (+)
PWK/PhJ	MGP_PWKPhJ_G0032793	protein coding gene	Chr8:102973933-103017148 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032634	protein coding gene	Chr8:105902673-105950079 (+)
WSB/EiJ	MGP_WSBEiJ_G0033208	protein coding gene	Chr8:107886488-107932311 (+)

Human Ortholog

PRMT7, protein arginine methyltransferase 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRMT7, protein arginine methyltransferase 7
Synonyms

SBIDDS
Links

HGNC:25557

NCBI Gene ID: 54496

neXtProt AC: NX_Q9NVM4

UniProt: Q9NVM4
Chr Location

16q22.1; chr16:68310951-68360870 (+) GRCh38

MGI Vertebrate Homology

Prmt7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRMT7
Protein SuperFamily

Arg_N-mtase
Gene Tree

Prmt7

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Phenotype Summary

38 phenotypes from 3 alleles in 3 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Endonuclease-mediated

4
Gene trapped

14
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced body weight, increased epididymal fat pad weight, impaired myoblast differentiation, reduced satellite cells, early cellular replicative senescence in muscles and reduced muscle regeneration following injury.

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All GO Annotations

32
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

9
cDNA Data

7
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prmt7

ZFIN prmt7

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All Sequences

55
RefSeq

4
UniProt

5
CCDS

CCDS22633.1

Ensembl

ENSMUSG00000060098 (Evidence)
NCBI Gene

214572

			Length	Strain/Species	Flank
genomic	214572	NCBI Gene Model \| MGI Sequence Detail	40641	C57BL/6J	± kb
transcript	NM_145404	RefSeq \| MGI Sequence Detail	2269	FVB/N
polypeptide	Q922X9	UniProt \| EBI \| MGI Sequence Detail	692	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013257 protein arginine N-methyltransferase 7

(term hierarchy)
PDB

4C4A, 6OGN
EC

2.1.1.321
InterPro Domains

IPR025799 Protein arginine N-methyltransferase

IPR014644 Protein arginine N-methyltransferase PRMT7

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

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All nucleic 10

cDNA 10

Microarray probesets 5

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MGI:1918262

Summaries

All 65

Developmental Gene Expression 8

Gene Ontology 5

Phenotypes 25
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:338836 Li Q, et al., Prmt5 promotes ciliated cell specification of airway epithelial progenitors via transcriptional inhibition of Tp63. J Biol Chem. 2023 Jun 24;299(8):104964

TSS for Prmt7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79236	Chr8:106936776-106936783 (+)	-906 bp
Tssr79237	Chr8:106937592-106937606 (+)	-87 bp
Tssr79238	Chr8:106937625-106937643 (+)	-52 bp
Tssr79239	Chr8:106937648-106937675 (+)	-24 bp
Tssr79240	Chr8:106969909-106969917 (+)	32,227 bp
Tssr79241	Chr8:106969932-106969943 (+)	32,252 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23