Il27
Gene Detail

Symbol Name ID

Il27 interleukin 27 MGI:2384409

Synonyms

IL-27, IL-27p28, Il30, p28

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:126589010-126594941 bp, - strand From VEGA annotation of GRCm38   5932 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:17087  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: interleukin-27, subunit alpha
Gene Tree: Il27

Human homologs

Human Homolog		IL27, interleukin 27
NCBI Gene ID		246778
neXtProt AC		NX_Q8NEV9
Human Synonyms		IL-27, IL27A, IL-27A, IL27p28, IL30, p28
Human Chr (Location)		16p11; chr16:28510683-28518155 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a knock-out allele develop an exaggerated delayed-type hypersensitivity response and are more susceptible to experimental autoimmune encephalomyelitis due to the presence of an increased number of Th17 cells.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	inflammatory response, innate immune response, ...
Component	extracellular region, extracellular space
Function	cytokine activity, interleukin-27 receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (16)    Tissues (7)   
Theiler Stages: 6, 8, 28

Assay Type	Results
RT-PCR	16

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000029446 (Evidence)
Ensembl Gene Model	ENSMUSG00000044701 (Evidence)
Entrez Gene	246779 (Evidence)
UniGene	222632
DFCI	TC1620534
NIA Mouse Gene Index	U029252
Consensus CDS Project	CCDS21835.1
International Mouse Knockout Project Status	Il27

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029446	VEGA Gene Model | MGI Sequence Detail	5932	C57BL/6J
transcript	OTTMUST00000072967	VEGA | MGI Sequence Detail	1021	Not Applicable
polypeptide	OTTMUSP00000037686	VEGA | MGI Sequence Detail	234	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(43 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026207	Interleukin-27 subunit alpha
Protein Ontology	PR:000001385	interleukin-27 subunit alpha

References

(Earliest) J:77522 Pflanz S, et al., IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4(+) T Cells. Immunity. 2002 Jun;16(6):779-90
(Latest) J:191233 Perona-Wright G, et al., Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18535-40
All references(45)