About   Help   FAQ
Il27
Gene Detail
Symbol

Name
ID
Il27
interleukin 27
MGI:2384409
Synonyms
IL-27, IL-27p28, Il30, p28
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:126589010-126594941 bp, - strand
From VEGA annotation of GRCm38

  5932 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17087  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: IL27
Protein SuperFamily: interleukin-27, subunit alpha
Gene Tree: Il27

Human
homologs
IL27, interleukin 27
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 246778
neXtProt AC: NX_Q8NEV9

Human Synonyms: IL-27, IL27A, IL-27A, IL27p28, IL30, p28

Human Chr (Location): 16p11; chr16:28499069-28526399 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele develop an exaggerated delayed-type hypersensitivity response and are more susceptible to experimental autoimmune encephalomyelitis due to the presence of an increased number of Th17 cells.
 
Interactions
Il27 interacts with 30 markers (Mir27a, Mir133a-1, Mir133a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process immune system process, inflammatory response, ...
Component extracellular region, extracellular space
Function cytokine activity, interleukin-27 receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (16)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 16
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000029446 (Evidence)
Ensembl Gene Model ENSMUSG00000044701 (Evidence)
Entrez Gene 246779 (Evidence)
UniGene 222632
DFCI TC1620534
NIA Mouse Gene Index U029252
Consensus CDS Project CCDS21835.1
International Mouse Phenotyping Consortium Status Il27
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029446 VEGA Gene Model | MGI Sequence Detail 5932 C57BL/6J ±  kb
transcript OTTMUST00000072967 VEGA | MGI Sequence Detail 1021 Not Applicable 
polypeptide OTTMUSP00000037686 VEGA | MGI Sequence Detail 234 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026207 Interleukin-27 subunit alpha
Protein Ontology PR:000001385 interleukin-27 subunit alpha
References
(Earliest) J:77522 Pflanz S, et al., IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4(+) T Cells. Immunity. 2002 Jun;16(6):779-90
(Latest) J:197331 Wu C, et al., Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7802-7
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory