About   Help   FAQ
Il27 Gene Detail
Summary
  • Symbol
    Il27
  • Name
    interleukin 27
  • Synonyms
    IL-27, IL-27p28, Il30, p28
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384409
    NCBI Gene: 246779
  • Gene Overview
    MyGene.info: IL27
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126589010-126594941 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384409
protein coding gene Chr7:126589009-126595021 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032988
protein coding gene Chr7:130872282-130878216 (-)
A/J MGP_AJ_G0032971
protein coding gene Chr7:127409681-127415607 (-)
AKR/J MGP_AKRJ_G0032903
protein coding gene Chr7:130632471-130638397 (-)
BALB/cJ MGP_BALBcJ_G0032976
protein coding gene Chr7:127067160-127073091 (-)
C3H/HeJ MGP_C3HHeJ_G0032686
protein coding gene Chr7:130562188-130568105 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033482
protein coding gene Chr7:135962378-135968324 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030454
protein coding gene Chr7:128599363-128605540 (-)
CAST/EiJ MGP_CASTEiJ_G0032014
protein coding gene Chr7:122355824-122361566 (-)
CBA/J MGP_CBAJ_G0032659
protein coding gene Chr7:140534053-140539998 (-)
DBA/2J MGP_DBA2J_G0032811
protein coding gene Chr7:125385643-125391572 (-)
FVB/NJ MGP_FVBNJ_G0032764
protein coding gene Chr7:125235347-125241982 (-)
LP/J MGP_LPJ_G0032905
protein coding gene Chr7:132337085-132343008 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032796
protein coding gene Chr7:141722152-141728107 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033501
protein coding gene Chr7:129649088-129654975 (-)
PWK/PhJ MGP_PWKPhJ_G0031722
protein coding gene Chr7:118373716-118379775 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031568
protein coding gene Chr7:116477690-116483631 (-)
WSB/EiJ MGP_WSBEiJ_G0032127
protein coding gene Chr7:130616521-130622446 (-)



Homology
more
  • Human Ortholog
    IL27, interleukin 27
  • Vertebrate Orthologs
    6
  • Human Ortholog
    IL27, interleukin 27
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL-27, IL27A, IL-27A, IL27p28, IL30, p28
  • Links
    NCBI Gene ID: 246778
    neXtProt AC: NX_Q8NEV9
    UniProt: Q8NEV9

  • Chr Location
    16p12.1-p11.2; chr16:28499362-28526730 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop an exaggerated delayed-type hypersensitivity response and are more susceptible to experimental autoimmune encephalomyelitis due to the presence of an increased number of Th17 cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044701 Ensembl Gene Model | MGI Sequence Detail 5932 C57BL/6J ±  kb
    transcript ENSMUST00000058429 Ensembl | MGI Sequence Detail 1021 Not Applicable  
    polypeptide ENSMUSP00000054637 Ensembl | MGI Sequence Detail 234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:77522 Pflanz S, et al., IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4(+) T Cells. Immunity. 2002 Jun;16(6):779-90
    • Latest
      J:253426 Nguyen TH, et al., Identification of IFN-gamma and IL-27 as Critical Regulators of Respiratory Syncytial Virus-Induced Exacerbation of Allergic Airways Disease in a Mouse Model. J Immunol. 2018 Jan 1;200(1):237-247

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory