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Il27
Gene Detail
Symbol

Name
ID
Il27
interleukin 27
MGI:2384409
Synonyms
IL-27, IL-27p28, Il30, p28
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:126589010-126594941 bp, - strand
From VEGA annotation of GRCm38

  5932 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17087  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: interleukin-27, subunit alpha
Gene Tree: Il27

Human
homologs
Human Homolog IL27, interleukin 27
NCBI Gene ID 246778
neXtProt AC  NX_Q8NEV9
Human Synonyms  IL-27, IL27A, IL-27A, IL27p28, IL30, p28
Human Chr (Location)  16p11; chr16:28499362-28506834 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele develop an exaggerated delayed-type hypersensitivity response and are more susceptible to experimental autoimmune encephalomyelitis due to the presence of an increased number of Th17 cells.
 
Interactions
Il27 interacts with 30 markers (Mir27a, Mir133a-1, Mir133a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process immune system process, inflammatory response, ...
Component extracellular region, extracellular space
Function cytokine activity, interleukin-27 receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (16)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 16
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000029446 (Evidence)
Ensembl Gene ModelENSMUSG00000044701 (Evidence)
Entrez Gene246779 (Evidence)
UniGene222632
DFCITC1620534
NIA Mouse Gene IndexU029252
Consensus CDS ProjectCCDS21835.1
International Mouse Knockout Project StatusIl27
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029446 VEGA Gene Model | MGI Sequence Detail 5932 C57BL/6J ±  kb
transcript OTTMUST00000072967 VEGA | MGI Sequence Detail 1021 Not Applicable 
polypeptide OTTMUSP00000037686 VEGA | MGI Sequence Detail 234 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026207 Interleukin-27 subunit alpha
Protein Ontology PR:000001385 interleukin-27 subunit alpha
References
(Earliest) J:77522 Pflanz S, et al., IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4(+) T Cells. Immunity. 2002 Jun;16(6):779-90
(Latest) J:197331 Wu C, et al., Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7802-7
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory