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Il27 Gene Detail
Summary
  • Symbol
    Il27
  • Name
    interleukin 27
  • Synonyms
    IL-27, IL-27p28, Il30, p28
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384409
    NCBI Gene: 246779
  • Gene Overview
    MyGene.info: IL27
Location & Maps
more
  • Sequence Map
    Chr7:126589010-126594941 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5932 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IL27, interleukin 27
  • Vertebrate Orthologs
    6
  • Human Ortholog
    IL27, interleukin 27
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IL-27, IL27A, IL-27A, IL27p28, IL30, p28
  • Links
    NCBI Gene ID: 246778
    neXtProt AC: NX_Q8NEV9

  • Chr Location
    16p11; chr16:28499069-28526399 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    1
  • Targeted
    5
  • Transgenic
    1
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele develop an exaggerated delayed-type hypersensitivity response and are more susceptible to experimental autoimmune encephalomyelitis due to the presence of an increased number of Th17 cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029446 VEGA Gene Model | MGI Sequence Detail 5932 C57BL/6J ±  kb
transcript OTTMUST00000072967 VEGA | MGI Sequence Detail 1021 Not Applicable  
polypeptide OTTMUSP00000037686 VEGA | MGI Sequence Detail 234 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    64 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001385 interleukin-27 subunit alpha
  • InterPro Domains
    IPR026207 Interleukin-27 alpha
Molecular
Reagents
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  • All nucleic 5
    cDNA 4
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 52
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:77522 Pflanz S, et al., IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4(+) T Cells. Immunity. 2002 Jun;16(6):779-90
  • Latest
    J:213920 Hemmerle T, et al., Antibody-based delivery of IL4 to the neovasculature cures mice with arthritis. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12008-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory