Alkbh1
Gene Detail

Symbol Name ID

Alkbh1 alkB, alkylation repair homolog 1 (E. coli) MGI:2384034

BioType Conflict

Synonyms

alkB, Alkbh, Nrp

Feature Type

protein coding gene

Genetic Map

Chromosome 12

41.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr12:87428077-87443839 bp, - strand From NCBI annotation of GRCm38   15763 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4393  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Human homologs

Human Homolog		ALKBH1, alkB, alkylation repair homolog 1 (E. coli)
NCBI Gene ID		8846
neXtProt AC		NX_Q13686
Human Synonyms		ABH, ABH1, alkB, ALKBH, hABH
Human Chr (Location)		14q24.3; chr14:78138749-78174356 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(19) : Targeted(5) Gene trapped(14)
 

Mice homozygous for a null allele show delayed fetal growth, impaired placental development and low birth weight. Mice homozygous for another null allele show sex-ratio distortion, reduced survival, spermatogenic defects and incompletely penetrant eye, neural tube, skeleton and craniofacial defects.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	cell differentiation, developmental growth, ...
Component	mitochondrion, nuclear euchromatin, ...
Function	catalytic activity, chemoattractant activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) Genomic(1) cDNA(9)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000033357 (Evidence), OTTMUSG00000039951 (Evidence)
Ensembl Gene Model	ENSMUSG00000093396 (Evidence), ENSMUSG00000079036 (Evidence)
Entrez Gene	211064 (Evidence)
EC	1.14.11.33, 4.2.99.18
Consensus CDS Project	CCDS49120.1
International Mouse Knockout Project Status	Alkbh1

Sequences

Length	Strain/Species
genomic	211064	NCBI Gene Model | MGI Sequence Detail	15763	C57BL/6J
transcript	NM_001102565	RefSeq | MGI Sequence Detail	1968	C57BL/6
polypeptide	P0CB42	UniProt | EBI | MGI Sequence Detail	389	Not Applicable

All sequences(60) RefSeq(2) UniProt(6)

Protein-related information

Resource	ID	Description
InterPro	IPR004574	Alkylated DNA repair protein AlkB
InterPro	IPR005123	Oxoglutarate/iron-dependent dioxygenase
Protein Ontology	PR:000033880	alkylated DNA repair protein alkB homolog 1

Graphical View of Protein Domain Structure

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:194644 Ougland R, et al., ALKBH1 is a histone H2A dioxygenase involved in neural differentiation. Stem Cells. 2012 Dec;30(12):2672-82
All references(31)