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Alkbh1
Gene Detail
Symbol

Name
ID
Alkbh1
alkB, alkylation repair homolog 1 (E. coli)
MGI:2384034
Synonyms
alkB, Alkbh, Nrp
Feature Type
protein coding gene
Genetic Map
Chromosome 12
41.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:87425840-87444017 bp, - strand
From VEGA annotation of GRCm38

  18178 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4393  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Alkbh1

Human
homologs
Human Homolog ALKBH1, alkB, alkylation repair homolog 1 (E. coli)
NCBI Gene ID 8846
neXtProt AC  NX_Q13686
Human Synonyms  ABH, ABH1, alkB, ALKBH, hABH
Human Chr (Location)  14q24.3; chr14:77672406-77708022 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(15) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele show delayed fetal growth, impaired placental development and low birth weight. Mice homozygous for another null allele show sex-ratio distortion, reduced survival, spermatogenic defects and incompletely penetrant eye, neural tube, skeleton and craniofacial defects.
 
Phenotype Images(4)
Interactions
Alkbh1 interacts with 286 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell differentiation, developmental growth, ...
Component mitochondrion, nuclear euchromatin
Function chemoattractant activity, DNA-(apurinic or apyrimidinic site) lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) Genomic(1) cDNA(9)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000033357 (Evidence)
Ensembl Gene ModelENSMUSG00000079036 (Evidence)
Entrez Gene211064 (Evidence)
Consensus CDS ProjectCCDS49120.1
International Mouse Knockout Project StatusAlkbh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033357 VEGA Gene Model | MGI Sequence Detail 18178 C57BL/6J ±  kb
transcript OTTMUST00000083717 VEGA | MGI Sequence Detail 3857 Not Applicable 
polypeptide OTTMUSP00000045016 VEGA | MGI Sequence Detail 389 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(2)
Polymorphisms
SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000003948 alkylated DNA repair protein alkB homolog 1
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:204344 Muller TA, et al., ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination. PLoS One. 2013;8(6):e67403
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory