Sequence Detail

ID/Version

P0CB42 (UniProt | EBI)

Last sequence update: 2009-10-13
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Nucleic acid dioxygenase ALKBH1 {ECO:0000305}; EC=1.14.11.- {ECO:0000305|PubMed:27027282};AltName: Full=Alkylated DNA repair protein alkB homolog 1;AltName: Full=Alpha-ketoglutarate-dependent dioxygenase ABH1 {ECO:0000250|UniProtKB:Q

Provider

SWISS-PROT

Sequence

Polypeptide 389 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Alkbh1	alkB homolog 1, histone H2A dioxygenase	59	101	3	22

Sequence references in MGI

J:131022 Pan Z, et al., Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice. Dev Dyn. 2008 Feb;237(2):316-27
J:166841 Nordstrand LM, et al., Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. PLoS One. 2010;5(11):e13827
J:194644 Ougland R, et al., ALKBH1 is a histone H2A dioxygenase involved in neural differentiation. Stem Cells. 2012 Dec;30(12):2672-82
J:204344 Muller TA, et al., ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination. PLoS One. 2013;8(6):e67403
J:276409 Wu TP, et al., DNA methylation on N(6)-adenine in mammalian embryonic stem cells. Nature. 2016 Apr 21;532(7599):329-33
J:276420 Liu F, et al., ALKBH1-Mediated tRNA Demethylation Regulates Translation. Cell. 2016 Oct 20;167(3):816-828.e16