Myo3a
Gene Detail

Symbol Name ID

Myo3a myosin IIIA MGI:2183924

Synonyms

9030416P08Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

15.15 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:22227505-22618247 bp, + strand From VEGA annotation of GRCm38   390743 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49486  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Myo3a

Human homologs

Human Homolog		MYO3A, myosin IIIA
NCBI Gene ID		53904
neXtProt AC		NX_Q8NEV4
Human Synonyms		DFNB30
Human Chr (Location)		10p11.1; chr10:26223002-26501465 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MYO3A

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-in allele exhibit impaired hearing and cochlear hair cell degeneration.

 
Human Diseases Modeled Using Mouse Myo3a (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	inner ear development, peptidyl-serine phosphorylation, ...
Component	cytoplasm, cytoskeleton, ...
Function	actin binding, actin-dependent ATPase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (3)   
Theiler Stages: 25, 26, 28

Assay Type	Results
RT-PCR	7

cDNA source data(2)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(3) cDNA(2) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000011499 (Evidence)
Ensembl Gene Model	ENSMUSG00000025716 (Evidence)
Entrez Gene	667663 (Evidence)
UniGene	330033
DFCI	TC1630884
DoTS	DT.101342928, DT.91402316
NIA Mouse Gene Index	U001447
EC	2.7.11.1
International Mouse Knockout Project Status	Myo3a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011499	VEGA Gene Model | MGI Sequence Detail	390743	C57BL/6J
transcript	OTTMUST00000026881	VEGA | MGI Sequence Detail	2270	Not Applicable
polypeptide	OTTMUSP00000012266	VEGA | MGI Sequence Detail	753	Not Applicable

All sequences(32) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(881 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR001609	Myosin head, motor domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Protein Ontology	PR:000010863	myosin-IIIa

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:182310 Merritt RC, et al., Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Curr Biol. 2012 Feb 21;22(4):320-5
All references(30)

Other accession IDs

MGI:1918799