About   Help   FAQ
Myo3a
Gene Detail
 Symbol
Name
ID
Myo3a
myosin IIIA
MGI:2183924
Synonyms 9030416P08Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
15.15 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:22227505-22618247 bp, + strand
From VEGA annotation of GRCm38

  390743 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49486  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Myo3a

Human
homologs
Human Homolog MYO3A, myosin IIIA
NCBI Gene ID 53904
neXtProt AC  NX_Q8NEV4
Human Synonyms  DFNB30
Human Chr (Location)  10p11.1; chr10:25934073-26212536 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYO3A
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit impaired hearing and cochlear hair cell degeneration.
 
Human Diseases Modeled Using Mouse Myo3a (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Myo3a interacts with 67 markers (Mir10a, Mir10b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process ATP catabolic process, inner ear development, ...
Component cytoplasm, cytoskeleton, ...
Function actin binding, actin-dependent ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (4)   
Theiler Stages: 25, 26, 27, 28
Assay TypeResults
RT-PCR 7
cDNA source data(2)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(3) cDNA(2) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000011499 (Evidence)
Ensembl Gene ModelENSMUSG00000025716 (Evidence)
Entrez Gene667663 (Evidence)
UniGene330033
DFCITC1630884
DoTSDT.101342928, DT.91402316
NIA Mouse Gene IndexU001447
EC2.7.11.1
International Mouse Knockout Project StatusMyo3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011499 VEGA Gene Model | MGI Sequence Detail 390743 C57BL/6J ±  kb
transcript OTTMUST00000026881 VEGA | MGI Sequence Detail 2270 Not Applicable 
polypeptide OTTMUSP00000012266 VEGA | MGI Sequence Detail 753 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(1287 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1291)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology PR:000010863 myosin-IIIa
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:182310 Merritt RC, et al., Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Curr Biol. 2012 Feb 21;22(4):320-5
All references(30)
Disease annotation references (1)
Other
accession IDs
MGI:1918799

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory