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Nrbp1 Gene Detail
Summary
  • Symbol
    Nrbp1
  • Name
    nuclear receptor binding protein 1
  • Synonyms
    B230344L17Rik, MGC:6961, Nrbp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183436
    NCBI Gene: 192292
  • Gene Overview
    MyGene.info: NRBP1
Location & Maps
more
  • Sequence Map
    Chr5:31240864-31251566 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10703 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.27 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NRBP1, nuclear receptor binding protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NRBP1, nuclear receptor binding protein 1
    Orthology source: HomoloGene
  • Synonyms
    BCON3, MADM, MUDPNP, NRBP
  • Links
    NCBI Gene ID: 29959
    neXtProt AC: NX_Q9UHY1

  • Chr Location
    2p23; chr2:27428606-27442259 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8373
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NRBP1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    10
  • Genomic Mutations
    6 involving Nrbp1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit embryonic lethality at E7.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022515 VEGA Gene Model | MGI Sequence Detail 10703 C57BL/6J ±  kb
transcript OTTMUST00000053910 VEGA | MGI Sequence Detail 2221 Not Applicable  
polypeptide OTTMUSP00000025667 VEGA | MGI Sequence Detail 543 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    30 from dbSNP Build 142
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000011418 nuclear receptor-binding protein
  • InterPro Domains
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2444003
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 30
  • Earliest
    J:76031 De Langhe S, et al., Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. Int J Mol Med. 2002 May;9(5):451-9
  • Latest
    J:184685 Wilson CH, et al., Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J. 2012;31(11):2486-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory