Nrbp1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nrbp1
nuclear receptor binding protein 1
MGI:2183436

27 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nrbp1^tm1.1Dja/Nrbp1^tm1.1Dja Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J	abnormal crypts of Lieberkuhn morphology	J:184685
	abnormal enterocyte proliferation	J:184685
	abnormal intestinal enteroendocrine cell morphology	J:184685
	abnormal intestinal goblet cell morphology	J:184685
	abnormal intestinal mucosa morphology	J:184685
	abnormal intestine morphology	J:184685
	abnormal liver morphology	J:184685
	decreased tumor-free survival time	J:184685
	distended stomach	J:184685
	ectopic Paneth cells	J:184685
	increased gastrointestinal tumor incidence	J:184685
	increased leukemia incidence	J:184685
	increased lung carcinoma incidence	J:184685
	increased lymphoma incidence	J:184685
	increased tumor incidence	J:184685
	intestinal edema	J:184685
Nrbp1^tm1.1Dja/Nrbp1^tm1.2Dja Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J	abnormal crypts of Lieberkuhn morphology	J:184685
	abnormal enterocyte proliferation	J:184685
	abnormal intestinal enteroendocrine cell morphology	J:184685
	abnormal intestinal goblet cell morphology	J:184685
	abnormal intestinal mucosa morphology	J:184685
	abnormal intestine morphology	J:184685
	abnormal liver morphology	J:184685
	decreased tumor-free survival time	J:184685
	distended stomach	J:184685
	ectopic Paneth cells	J:184685
	increased gastrointestinal tumor incidence	J:184685
	increased leukemia incidence	J:184685
	increased lung carcinoma incidence	J:184685
	increased lymphoma incidence	J:184685
	increased tumor incidence	J:184685
	intestinal edema	J:184685
Nrbp1^tm1.1Dja/Nrbp1^tm1.2Dja Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J	abnormal intestinal goblet cell morphology	J:184685
	abnormal intestine morphology	J:184685
	abnormal Paneth cell morphology	J:184685
	ectopic Paneth cells	J:184685
Nrbp1^tm1.2Dja/Nrbp1^tm1.2Dja involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	embryonic lethality between implantation and somite formation, complete penetrance	J:184685
Nrbp1^{tm3b(EUCOMM)Wtsi}/Nrbp1⁺ C57BL/6N-Nrbp1^{tm3b(EUCOMM)Wtsi}/Wtsi	decreased CD4-positive, alpha-beta T cell number	J:211773
	increased CD8-positive, alpha-beta T cell number	J:211773
	increased grip strength	J:211773
Nrbp1^{tm3b(EUCOMM)Wtsi}/Nrbp1^{tm3b(EUCOMM)Wtsi} C57BL/6N-Nrbp1^{tm3b(EUCOMM)Wtsi}/Wtsi	abnormal chorion morphology	J:261316
	abnormal placenta morphology	J:261316
	abnormal trophoblast giant cell morphology	J:261316
	abnormal trophoblast layer morphology	J:261316
	lethality throughout fetal growth and development, complete penetrance	J:261316
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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