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Rspo1 Gene Detail
Summary
  • Symbol
    Rspo1
  • Name
    R-spondin 1
  • Synonyms
    Rspondin, R-spondin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183426
    NCBI Gene: 192199
  • Gene Overview
    MyGene.info: RSPO1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:124986430-125009099 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 57.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183426
protein coding gene Chr4:124986397-125009102 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028760
protein coding gene Chr4:126563154-126585792 (+)
A/J MGP_AJ_G0028719
protein coding gene Chr4:121587059-121609677 (+)
AKR/J MGP_AKRJ_G0028672
protein coding gene Chr4:124925078-124949762 (+)
BALB/cJ MGP_BALBcJ_G0028742
protein coding gene Chr4:122169776-122192310 (+)
C3H/HeJ MGP_C3HHeJ_G0028456
protein coding gene Chr4:125001049-125023707 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029184
protein coding gene Chr4:131425068-131447690 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026457
protein coding gene Chr4:114756207-114779349 (+)
CAST/EiJ MGP_CASTEiJ_G0027889
protein coding gene Chr4:123071351-123093996 (+)
CBA/J MGP_CBAJ_G0028422
protein coding gene Chr4:134704860-134730223 (+)
DBA/2J MGP_DBA2J_G0028571
protein coding gene Chr4:122060172-122082874 (+)
FVB/NJ MGP_FVBNJ_G0028538
protein coding gene Chr4:120690130-120712788 (+)
LP/J MGP_LPJ_G0028672
protein coding gene Chr4:126849173-126871799 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028564
protein coding gene Chr4:139681564-139704599 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029222
protein coding gene Chr4:125276056-125298697 (+)
PWK/PhJ MGP_PWKPhJ_G0027610
protein coding gene Chr4:118488039-118511241 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027436
protein coding gene Chr4:121051642-121074916 (+)
WSB/EiJ MGP_WSBEiJ_G0027969
protein coding gene Chr4:125356803-125379455 (+)



Homology
more
  • Human Ortholog
    RSPO1, R-spondin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RSPO1, R-spondin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRISTIN3, RSPO
  • Links
    NCBI Gene ID: 284654
    neXtProt AC: NX_Q2MKA7
    UniProt: Q2MKA7

  • Chr Location
    1p34.3; chr1:37611350-37634923 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 52148
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RSPO1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to abnormal ovarian development and masculinized features including pseudohermaphroditism in genital ducts, depletion of fetal oocytes, male-like vascularization, and ectopic testosterone production in the ovaries.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028871 Ensembl Gene Model | MGI Sequence Detail 22670 C57BL/6J ±  kb
    transcript ENSMUST00000030687 Ensembl | MGI Sequence Detail 1834 Not Applicable  
    polypeptide ENSMUSP00000030687 Ensembl | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 15
      Primer pair 3
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 58
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:278245 Guo Q, et al., Defining developmental diversification of diencephalon neurons through single cell gene expression profiling. Development. 2019 Apr 1;146(12)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/10/2019
    MGI 6.14
    The Jackson Laboratory