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Rspo1
Gene Detail
 Symbol
Name
ID
Rspo1
R-spondin homolog (Xenopus laevis)
MGI:2183426
Synonyms Rspondin, R-spondin
Feature Type protein coding gene
Genetic Map
Chromosome 4
57.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:124986430-125009099 bp, + strand
From VEGA annotation of GRCm38

  22670 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52148  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rspo1

Human
homologs
Human Homolog RSPO1, R-spondin 1
NCBI Gene ID 284654
neXtProt AC  NX_Q2MKA7
Human Synonyms  CRISTIN3, RSPO
Human Chr (Location)  1p34.3; chr1:37611350-37634923 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RSPO1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to abnormal ovarian development and masculinized features including pseudohermaphroditism in genital ducts, depletion of fetal oocytes, male-like vascularization, and ectopic testosterone production in the ovaries.
 
Interactions
Rspo1 interacts with 125 markers (Mir30a, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process canonical Wnt signaling pathway, male meiosis, ...
Component extracellular region, extracellular space, ...
Function G-protein coupled receptor binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (390)    Tissues (340)    Images (43)
Theiler Stages: 10, 11, 12, 13, 14, 15, 16, 17, 18, 20, 21, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 361
Northern blot 16
RT-PCR 5
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(14) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000009245 (Evidence)
Ensembl Gene ModelENSMUSG00000028871 (Evidence)
Entrez Gene192199 (Evidence)
UniGene42202
DFCITC1588113
DoTSDT.55237140
NIA Mouse Gene IndexU004794
Consensus CDS ProjectCCDS18633.1
International Mouse Knockout Project StatusRspo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009245 VEGA Gene Model | MGI Sequence Detail 22670 C57BL/6J ±  kb
transcript OTTMUST00000020932 VEGA | MGI Sequence Detail 1834 Not Applicable 
polypeptide OTTMUSP00000009593 VEGA | MGI Sequence Detail 265 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006212 Furin-like repeat
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000014330 R-spondin-1
References (Earliest) J:77554 Kamata T, et al., R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Biochim Biophys Acta. 2004 Jan 5;1676(1):51-62
(Latest) J:203797 Maatouk DM, et al., Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary. Dev Biol. 2013 Nov 15;383(2):295-306
All references(74)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory