Serpina3b
Gene Detail

Symbol Name ID

Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B MGI:2182835

Synonyms

6A1, A030003A19Rik, alpha-1 antiproteinase, antitrypsin

Feature Type

protein coding gene

Genetic Map

Chromosome 12

53.40 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:104127996-104139545 bp, + strand From VEGA annotation of GRCm38   11550 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:120222  Vertebrate Homology Class
2 mouse

Protein SuperFamily: serpin
Gene Tree: Serpina3b

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component	extracellular region
Function	peptidase inhibitor activity, serine-type endopeptidase inhibitor activity

External Resources: FuncBase

Expression

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(4) cDNA(4)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000027589 (Evidence)
Ensembl Gene Model	ENSMUSG00000066364 (Evidence)
Entrez Gene	271047 (Evidence)
UniGene	120265
DFCI	TC1593686
DoTS	DT.94148296
NIA Mouse Gene Index	U119116
Consensus CDS Project	CCDS26147.1
International Mouse Knockout Project Status	Serpina3b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027589	VEGA Gene Model | MGI Sequence Detail	11550	C57BL/6J
transcript	OTTMUST00000068302	VEGA | MGI Sequence Detail	2070	Not Applicable
polypeptide	OTTMUSP00000034498	VEGA | MGI Sequence Detail	420	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(127 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000015934	serine protease inhibitor A3B

References

(Earliest) J:82699 Forsyth S, et al., A review and comparison of the murine alpha(1)-antitrypsin and alpha(1)-antichymotrypsin multigene clusters with the human clade A serpins. Genomics. 2003 Mar;81(3):336-45
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(23)

Other accession IDs

MGI:3045329