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Tpcn1 Gene Detail
Summary
  • Symbol
    Tpcn1
  • Name
    two pore channel 1
  • Synonyms
    5730403B01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182472
    NCBI Gene: 252972
  • Gene Overview
    MyGene.info: TPCN1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr5:120534153-120588673 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      54521 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.63 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TPCN1, two pore segment channel 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPCN1, two pore segment channel 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TPC1
  • Links
    NCBI Gene ID: 53373
    neXtProt AC: NX_Q9ULQ1
    UniProt: Q9ULQ1

  • Chr Location
    12q24.13; chr12:113221429-113298589 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 9905
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TPCN1
  • Gene Tree
    Tpcn1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    21 phenotype references
Homozygous inactivation of this gene results in no apparent phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    49
  • Tissues
    29
  • cDNA Data
    89
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056260 VEGA Gene Model | MGI Sequence Detail 54521 C57BL/6J ±  kb
transcript OTTMUST00000139033 VEGA | MGI Sequence Detail 4712 Not Applicable  
polypeptide OTTMUSP00000073000 VEGA | MGI Sequence Detail 817 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 99
    Genomic 6
    cDNA 90
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:2443784
References
more
  • Summaries
    All 48
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 21
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/09/2018
MGI 6.12 		The Jackson Laboratory