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Tpcn1 Gene Detail
Summary
  • Symbol
    Tpcn1
  • Name
    two pore channel 1
  • Synonyms
    5730403B01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182472
    NCBI Gene: 252972
  • Gene Overview
    MyGene.info: TPCN1
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:120534153-120588673 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182472
 protein coding gene Chr5:120534153-120588698 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030006
 protein coding gene Chr5:123891442-123971349 (-)
A/J MGP_AJ_G0029970
 protein coding gene Chr5:118779361-118834369 (-)
AKR/J MGP_AKRJ_G0029909
 protein coding gene Chr5:122609179-122669902 (-)
BALB/cJ MGP_BALBcJ_G0029981
 protein coding gene Chr5:120194701-120251794 (-)
C3H/HeJ MGP_C3HHeJ_G0029701
 protein coding gene Chr5:123142292-123206143 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030436
 protein coding gene Chr5:128556218-128625233 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027662
 protein coding gene Chr5:113487088-113544261 (-)
CAST/EiJ MGP_CASTEiJ_G0029110
 protein coding gene Chr5:122269215-122331455 (-)
CBA/J MGP_CBAJ_G0029669
 protein coding gene Chr5:133540828-133615343 (-)
DBA/2J MGP_DBA2J_G0029819
 protein coding gene Chr5:118863162-118919053 (-)
FVB/NJ MGP_FVBNJ_G0029775
 protein coding gene Chr5:117785650-117844501 (-)
LP/J MGP_LPJ_G0029907
 protein coding gene Chr5:124363153-124422218 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029806
 protein coding gene Chr5:137516238-137580149 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030477
 protein coding gene Chr5:122186261-122248428 (-)
PWK/PhJ MGP_PWKPhJ_G0028823
 protein coding gene Chr5:117623668-117680105 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028662
 protein coding gene Chr5:119851177-119907534 (-)
WSB/EiJ MGP_WSBEiJ_G0029185
 protein coding gene Chr5:122776279-122841592 (-)



Homology
more
  • Human Ortholog
    TPCN1, two pore segment channel 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPCN1, two pore segment channel 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TPC1
  • Links
    NCBI Gene ID: 53373
    neXtProt AC: NX_Q9ULQ1
    UniProt: Q9ULQ1

  • Chr Location
    12q24.13; chr12:113221429-113298589 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 9905
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TPCN1
  • Gene Tree
    Tpcn1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    21 phenotype references
Homozygous inactivation of this gene results in no apparent phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    49
  • Tissues
    29
  • cDNA Data
    89
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032741 Ensembl Gene Model | MGI Sequence Detail 54521 C57BL/6J ±  kb
transcript ENSMUST00000046426 Ensembl | MGI Sequence Detail 4712 Not Applicable  
polypeptide ENSMUSP00000042188 Ensembl | MGI Sequence Detail 817 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 99
    Genomic 6
    cDNA 90
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:2443784
References
more
  • Summaries
    All 48
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/04/2018
MGI 6.13 		The Jackson Laboratory