Sequence Detail

ID/Version

Q9EQJ0 Q3V2Z6 Q6ZPW5 (UniProt | EBI)

Last sequence update: 2001-03-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Two pore calcium channel protein 1 {ECO:0000305};AltName: Full=Voltage-dependent calcium channel protein TPC1;

Provider

SWISS-PROT

Sequence

Polypeptide 817 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tpcn1	two pore channel 1	34	103	3	23

Sequence references in MGI

J:77001 Perelygin AA, et al., Positional cloning of the murine flavivirus resistance gene. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9322-7
J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:189070 Wang X, et al., TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes. Cell. 2012 Oct 12;151(2):372-83
J:193600 Cang C, et al., mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na(+) Channels to Adapt to Metabolic State. Cell. 2013 Feb 14;152(4):778-90
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306587 Sakurai Y, et al., Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science. 2015 Feb 27;347(6225):995-8
J:306593 Castonguay J, et al., The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes. Sci Rep. 2017 Aug 30;7(1):10038
J:306709 Cang C, et al., The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nat Chem Biol. 2014 Jun;10(6):463-9