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Vrk3 Gene Detail
Summary
  • Symbol
    Vrk3
  • Name
    vaccinia related kinase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182465
    NCBI Gene: 101568
Location & Maps
more
  • Sequence Map
    Chr7:44748413-44777515 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29103 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.90 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    VRK3, vaccinia related kinase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VRK3, vaccinia related kinase 3
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 51231
    neXtProt AC: NX_Q8IV63

  • Chr Location
    19q13; chr19:49976467-50026017 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9509
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: VRK3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022259 VEGA Gene Model | MGI Sequence Detail 29103 C57BL/6J ±  kb
transcript OTTMUST00000052987 VEGA | MGI Sequence Detail 1969 Not Applicable  
polypeptide OTTMUSP00000025173 VEGA | MGI Sequence Detail 453 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    251 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000017351 inactive serine/threonine-protein kinase VRK3
  • InterPro Domains
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR026870 Zinc-ribbon domain
Molecular
Reagents
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  • All nucleic 104
    cDNA 102
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGI:2141945
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:83672 Vega FM, et al., Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. FEBS Lett. 2003 Jun 5;544(1-3):176-80
  • Latest
    J:230531 Park CH, et al., Presumed pseudokinase VRK3 functions as a BAF kinase. Biochim Biophys Acta. 2015 Jul;1853(7):1738-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory