Phenotypes Associated with This Genotype

Genotype
MGI:6112031

• Allelic Composition: Vrk3^{Gt(YTA189)Byg}/Vrk3^{Gt(YTA189)Byg}
• Genetic Background: B6.129P2-Vrk3^{Gt(YTA189)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal long-term spatial reference memory ( J:249352 )

• impaired spatial memory after 4 days of training in a Barnes circular maze

• however, exploratory behavior is similar to controls

abnormal fear/anxiety-related behavior ( J:249352 )

impaired passive avoidance behavior ( J:249352 )

• shorter step-through latencies to enter a dark chamber after training with an electric shock

decreased anxiety-related response ( J:249352 )

• spend more time in the center of an open field, the open arms of an elevated maze and the light side of a light-dark chamber

abnormal response to novel object ( J:249352 )

• decreased ability to discriminate between a familiar and novel object at 24h after training

increased grooming behavior ( J:249352 )

• longer duration of grooming behavior

• chronic treatment with 7,8-dihydroxyflavone reduces the length of grooming behavior

increased locomotor activity ( J:249352 )

• in an open field assay

abnormal social/conspecific interaction behavior ( J:249352 )

abnormal pup retrieval ( J:249352 )

• less efficient pup retrieval from a scattered nest compared to wild-type controls

abnormal nest building behavior ( J:249352 )

• less efficient in a nesting behavior assay compared to wild-type controls

abnormal social investigation ( J:249352 )

• do not show a preference for a chamber containing a novel mouse over an empty chamber in a three-chamber test

• chronic and acute treatment with 7,8-dihydroxyflavone substantially ameliorates social interaction deficits but not changes in anxiety related behavior

abnormal response to social novelty ( J:249352 )

• do not show a preference for a chamber containing a novel mouse over a chamber with a familiar mouse in a three-chamber test

nervous system

decreased dendritic spine density ( J:249352 )

• in the CA1 and dentate gyrus regions of the hippocampus

• treatment with 7,8-dihydroxyflavone restores the dendritic spine density to levels similar to controls

increased dendritic spine length ( J:249352 )

• marked increase in the length of all spine types in the CA1 region but not in the dentate gyrus region

abnormal hippocampal pyramidal neuron dendrite morphology ( J:249352 )

• decreased dendritic arborization in pyramidal neurons

abnormal postsynaptic density morphology ( J:249352 )

• in the hippocampal CA1 region postsynaptic densities length and thickness are reduced

abnormal AMPA-mediated synaptic currents ( J:249352 )

• decrease in the ratio of AMPA receptor?mediated currents measured at 40 and -70 mV holding potentials

• treatment with 7,8-dihydroxyflavone reverses the rectification of AMPA receptor mediated currents

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:249352