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Il23r
Gene Detail
Symbol

Name
ID
Il23r
interleukin 23 receptor
MGI:2181693
Feature Type
protein coding gene
Genetic Map
Chromosome 6
30.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:67422932-67491855 bp, - strand
From VEGA annotation of GRCm38

  68924 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16930  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: IL23R
Gene Tree: Il23r

Human
homologs
IL23R, interleukin 23 receptor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 149233
neXtProt AC: NX_Q5VWK5

Human Chr (Location): 1p31.3; chr1:67138640-67259979 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human IL23R

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Th17 T cells from homozygous null mice have less secretion of IL-9 upon secondary stimulation.
 
Interactions
Il23r interacts with 100 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(2)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN il23r    NEW 
Molecular
reagents
All nucleic(2) cDNA(2)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000029859 (Evidence)
Ensembl Gene Model ENSMUSG00000049093 (Evidence)
Entrez Gene 209590 (Evidence)
UniGene 221227
DoTS DT.101349629
NIA Mouse Gene Index U027413
Consensus CDS Project CCDS39503.2
International Mouse Phenotyping Consortium Status Il23r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029859 VEGA Gene Model | MGI Sequence Detail 68924 C57BL/6J ±  kb
transcript OTTMUST00000074102 VEGA | MGI Sequence Detail 2488 Not Applicable 
polypeptide OTTMUSP00000038453 VEGA | MGI Sequence Detail 659 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(415 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015321 Type I cytokine receptor, cytokine-binding domain
Protein Ontology PR:000009001 interleukin-23 receptor
References
(Earliest) J:76845 Parham C, et al., A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol. 2002 Jun 1;168(11):5699-708
(Latest) J:221887 Aychek T, et al., IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology. Nat Commun. 2015;6:6525
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory