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Il23r Gene Detail
Summary
  • Symbol
    Il23r
  • Name
    interleukin 23 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181693
    NCBI Gene: 209590
  • Gene Overview
    MyGene.info: IL23R
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:67422932-67491855 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 30.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    414 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181693
protein coding gene Chr6:67422932-67491855 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030846
protein coding gene Chr6:67423947-67506270 (-)
A/J MGP_AJ_G0030816
protein coding gene Chr6:64526058-64596132 (-)
AKR/J MGP_AKRJ_G0030744
protein coding gene Chr6:66534649-66608559 (-)
BALB/cJ MGP_BALBcJ_G0030827
protein coding gene Chr6:64885507-64963933 (-)
C3H/HeJ MGP_C3HHeJ_G0030885
protein coding gene Chr6:117528542-117607014 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031285
protein coding gene Chr6:69026743-69114894 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028474
protein coding gene Chr6:61672259-61740877 (-)
CAST/EiJ MGP_CASTEiJ_G0029935
protein coding gene Chr6:66826351-66903491 (-)
CBA/J MGP_CBAJ_G0030514
protein coding gene Chr6:71850524-71934123 (-)
DBA/2J MGP_DBA2J_G0030666
protein coding gene Chr6:64190168-64258167 (-)
FVB/NJ MGP_FVBNJ_G0030619
protein coding gene Chr6:63678351-63746056 (-)
LP/J MGP_LPJ_G0030745
protein coding gene Chr6:67380184-67453823 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030654
protein coding gene Chr6:75592153-75679511 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031311
protein coding gene Chr6:66456867-66533743 (-)
PWK/PhJ MGP_PWKPhJ_G0029650
protein coding gene Chr6:63369882-63443376 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029479
protein coding gene Chr6:66073666-66149191 (-)
WSB/EiJ MGP_WSBEiJ_G0030017
protein coding gene Chr6:66787515-66859999 (-)



Homology
more
  • Human Ortholog
    IL23R, interleukin 23 receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IL23R, interleukin 23 receptor
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 149233
    neXtProt AC: NX_Q5VWK5
    UniProt: Q5VWK5

  • Chr Location
    1p31.3; chr1:67138638-67259979 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human IL23R associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 5 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Th17 T cells from homozygous null mice have less secretion of IL-9 upon secondary stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 209590 NCBI Gene Model | MGI Sequence Detail 68924 C57BL/6J ±  kb
transcript NM_144548 RefSeq | MGI Sequence Detail 2488 C57BL/6  
polypeptide Q8K4B4 UniProt | EBI | MGI Sequence Detail 644 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
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  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 80
    Gene Ontology 6
    Phenotypes 54
  • Earliest
    J:76845 Parham C, et al., A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol. 2002 Jun 1;168(11):5699-708
  • Latest
    J:264503 Buchele V, et al., Targeting Inflammatory T Helper Cells via Retinoic Acid-Related Orphan Receptor Gamma t Is Ineffective to Prevent Allo-Response-Driven Colitis. Front Immunol. 2018;9:1138

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory