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Il23r Gene Detail
Summary
  • Symbol
    Il23r
  • Name
    interleukin 23 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181693
    NCBI Gene: 209590
  • Gene Overview
    MyGene.info: IL23R
Location & Maps
more
  • Sequence Map
    Chr6:67422932-67491855 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      68924 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 30.85 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    IL23R, interleukin 23 receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IL23R, interleukin 23 receptor
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 149233
    neXtProt AC: NX_Q5VWK5

  • Chr Location
    1p31.3; chr1:67138640-67259979 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human IL23R associations

Human Disease Mouse Models
       Inflammatory Bowel Disease 17; IBD17   OMIM: 612261
Psoriasis 7, Susceptibility To; PSORS7   OMIM: 605606
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 5 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Targeted
    9
  • Transgenic
    1
  • Incidental Mutations
Th17 T cells from homozygous null mice have less secretion of IL-9 upon secondary stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029859 VEGA Gene Model | MGI Sequence Detail 68924 C57BL/6J ±  kb
transcript OTTMUST00000074102 VEGA | MGI Sequence Detail 2488 Not Applicable  
polypeptide OTTMUSP00000038453 VEGA | MGI Sequence Detail 659 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    414 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009001 interleukin-23 receptor
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
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  • All nucleic 2
    cDNA 2

    Microarray probesets 1
References
more
  • Summaries
    All 55
    Gene Ontology 4
    Phenotypes 36
  • Earliest
    J:76845 Parham C, et al., A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol. 2002 Jun 1;168(11):5699-708
  • Latest
    J:233769 Lee JS, et al., Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability. Immunity. 2015 Oct 20;43(4):727-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory