Ccrl1
Gene Detail

Symbol Name ID

Ccrl1 chemokine (C-C motif) receptor-like 1 MGI:2181676

Synonyms

A630091E18Rik, CCBP2, CCR11, CCX-CKR, PPR1, VSHK1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

56.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:104098138-104126643 bp, - strand From NCBI annotation of GRCm38   28506 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: chemokine receptor

Human homologs

Human Homolog		CCRL1, chemokine (C-C motif) receptor-like 1
NCBI Gene ID		51554
neXtProt AC		NX_Q9NPB9
Human Synonyms		CCBP2, CC-CKR-11, CCR10, CCR11, CCR-11, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1
Human Chr (Location)		3q22; chr3:132316094-132321382 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls. Mice homozygous for a different knock-out allele exhibit increased susceptibility to experimental autoimmune encephalomyelitis with increased Th17 response.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	chemokine-mediated signaling pathway, chemotaxis, ...
Component	integral to membrane, membrane, ...
Function	chemokine binding, chemokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (249)    Tissues (116)    Images (71)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	145
In situ reporter (knock in)	66
RT-PCR	38

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000041748 (Evidence), ENSMUSG00000079355 (Evidence)
Entrez Gene	252837 (Evidence)
UniGene	269254
DFCI	TC1584593, TC1593626, TC1596584, TC1596586, TC1750196
DoTS	DT.521656, DT.91558103, DT.91588075, DT.94294899
NIA Mouse Gene Index	U031268
Consensus CDS Project	CCDS23459.1
International Mouse Knockout Project Status	Ccrl1

Sequences

Length	Strain/Species
genomic	252837	NCBI Gene Model | MGI Sequence Detail	28506	C57BL/6J
transcript	NM_145700	RefSeq | MGI Sequence Detail	2109	C57BL/6
polypeptide	Q924I3	UniProt | EBI | MGI Sequence Detail	350	Not Applicable

All sequences(32) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(102 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005383	CC chemokine receptor like 1
InterPro	IPR000355	Chemokine receptor family
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001213	chemokine receptor-like protein CCRL1

Graphical View of Protein Domain Structure

References

(Earliest) J:78206 Dorf ME, et al., Astrocytes express functional chemokine receptors. J Neuroimmunol. 2000 Nov 1;111(1-2):109-21
(Latest) J:193138 Bunting MD, et al., CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity. Blood. 2013 Jan 3;121(1):118-28
All references(35)

Other accession IDs

MGI:2441698