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Ackr4 Gene Detail
Summary
  • Symbol
    Ackr4
  • Name
    atypical chemokine receptor 4
  • Synonyms
    A630091E18Rik, CCBP2, CCR11, Ccrl1, CCX-CKR, PPR1, VSHK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181676
    NCBI Gene: 252837
  • Gene Overview
    MyGene.info: ACKR4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:104084157-104126933 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42777 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 56.47 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ACKR4, atypical chemokine receptor 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ACKR4, atypical chemokine receptor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCBP2, CC-CKR-11, CCR10, CCR11, CCR-11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1
  • Links
    NCBI Gene ID: 51554
    neXtProt AC: NX_Q9NPB9
    UniProt: Q9NPB9

  • Chr Location
    3q22.1; chr3:132597237-132602644 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls. Mice homozygous for a different knock-out allele exhibit increased susceptibility to experimental autoimmune encephalomyelitis with increased Th17 response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000049290 VEGA Gene Model | MGI Sequence Detail 42777 C57BL/6J ±  kb
    transcript OTTMUST00000125681 VEGA | MGI Sequence Detail 2396 Not Applicable  
    polypeptide OTTMUSP00000068058 VEGA | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      249 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2441698
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:78206 Dorf ME, et al., Astrocytes express functional chemokine receptors. J Neuroimmunol. 2000 Nov 1;111(1-2):109-21
    • Latest
      J:256707 Rodrigues PM, et al., Intrathymic Deletion of IL-7 Reveals a Contribution of the Bone Marrow to Thymic Rebound Induced by Androgen Blockade. J Immunol. 2018 Feb 15;200(4):1389-1398

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory