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Ackr4
Gene Detail
 Symbol
Name
ID
Ackr4
atypical chemokine receptor 4
MGI:2181676
Synonyms A630091E18Rik, CCBP2, CCR11, Ccrl1, CCX-CKR, PPR1, VSHK1
Feature Type protein coding gene
Genetic Map
Chromosome 9
56.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:104084157-104126933 bp, - strand
From VEGA annotation of GRCm38

  42777 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: chemokine receptor

Human
homologs
Human Homolog ACKR4, atypical chemokine receptor 4
NCBI Gene ID 51554
neXtProt AC  NX_Q9NPB9
Human Synonyms  CCBP2, CC-CKR-11, CCR10, CCR11, CCR-11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1
Human Chr (Location)  3q22; chr3:132597237-132602644 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls. Mice homozygous for a different knock-out allele exhibit increased susceptibility to experimental autoimmune encephalomyelitis with increased Th17 response.
 
Interactions
Ackr4 interacts with 285 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process chemokine-mediated signaling pathway, chemotaxis, ...
Component endosome, integral component of membrane, ...
Function chemokine binding, chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (249)    Tissues (116)    Images (71)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 145
In situ reporter (knock in) 66
RT-PCR 38
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000049290 (Evidence)
Ensembl Gene ModelENSMUSG00000041748 (Evidence), ENSMUSG00000079355 (Evidence)
Entrez Gene252837 (Evidence)
DFCITC1584593, TC1593626, TC1596584, TC1596586, TC1750196
DoTSDT.521656, DT.91558103, DT.91588075, DT.94294899
NIA Mouse Gene IndexU031268
Consensus CDS ProjectCCDS23459.1
International Mouse Knockout Project StatusAckr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049290 VEGA Gene Model | MGI Sequence Detail 42777 C57BL/6J ±  kb
transcript OTTMUST00000125682 VEGA | MGI Sequence Detail 2225 Not Applicable 
polypeptide OTTMUSP00000068059 VEGA | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(250 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005383 CC chemokine receptor like 1
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001213 C-C chemokine receptor type 11
References (Earliest) J:78206 Dorf ME, et al., Astrocytes express functional chemokine receptors. J Neuroimmunol. 2000 Nov 1;111(1-2):109-21
(Latest) J:193138 Bunting MD, et al., CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity. Blood. 2013 Jan 3;121(1):118-28
All references(36)
Other
accession IDs
MGI:2441698

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory