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Ackr4
Gene Detail
 Symbol
Name
ID
Ackr4
atypical chemokine receptor 4
MGI:2181676
Synonyms A630091E18Rik, CCBP2, CCR11, Ccrl1, CCX-CKR, PPR1, VSHK1
Feature Type protein coding gene
Genetic Map
Chromosome 9
56.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:104098138-104126643 bp, - strand
From NCBI annotation of GRCm38

  28506 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: chemokine receptor

Human
homologs
Human Homolog ACKR4, atypical chemokine receptor 4
NCBI Gene ID 51554
neXtProt AC  NX_Q9NPB9
Human Synonyms  CCBP2, CC-CKR-11, CCR10, CCR11, CCR-11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1
Human Chr (Location)  3q22; chr3:132597237-132602644 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls. Mice homozygous for a different knock-out allele exhibit increased susceptibility to experimental autoimmune encephalomyelitis with increased Th17 response.
 
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process chemokine-mediated signaling pathway, chemotaxis, ...
Component endosome, integral component of membrane, ...
Function chemokine binding, chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (249)    Tissues (116)    Images (71)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 145
In situ reporter (knock in) 66
RT-PCR 38
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000041748 (Evidence), ENSMUSG00000079355 (Evidence)
Entrez Gene252837 (Evidence)
DFCITC1584593, TC1593626, TC1596584, TC1596586, TC1750196
DoTSDT.521656, DT.91558103, DT.91588075, DT.94294899
NIA Mouse Gene IndexU031268
Consensus CDS ProjectCCDS23459.1
International Mouse Knockout Project StatusAckr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 252837 NCBI Gene Model | MGI Sequence Detail 28506 C57BL/6J ±  kb
transcript NM_145700 RefSeq | MGI Sequence Detail 2109 C57BL/6 
polypeptide Q924I3 UniProt | EBI | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005383 CC chemokine receptor like 1
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001213 C-C chemokine receptor type 11
Graphical View of Protein Domain Structure
References (Earliest) J:78206 Dorf ME, et al., Astrocytes express functional chemokine receptors. J Neuroimmunol. 2000 Nov 1;111(1-2):109-21
(Latest) J:193138 Bunting MD, et al., CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity. Blood. 2013 Jan 3;121(1):118-28
All references(35)
Other
accession IDs
MGI:2441698

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory