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Trpm8 Gene Detail
Summary
  • Symbol
    Trpm8
  • Name
    transient receptor potential cation channel, subfamily M, member 8
  • Synonyms
    CMR1, Trp-p8, TRPP8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181435
    NCBI Gene: 171382
  • Gene Overview
    MyGene.info: TRPM8
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:88306712-88388853 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    835 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181435
protein coding gene Chr1:88277661-88389293 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016285
protein coding gene Chr1:89697296-89812949 (+)
A/J MGP_AJ_G0016266
protein coding gene Chr1:86487215-86580368 (+)
AKR/J MGP_AKRJ_G0016227
protein coding gene Chr1:89027698-89135480 (+)
BALB/cJ MGP_BALBcJ_G0016222
protein coding gene Chr1:86624105-86718983 (+)
C3H/HeJ MGP_C3HHeJ_G0016051
protein coding gene Chr1:89271225-89362182 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016681
protein coding gene Chr1:93184362-93274886 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014399
protein coding gene Chr1:80791960-80879290 (+)
CAST/EiJ MGP_CASTEiJ_G0015636
protein coding gene Chr1:88482625-88635225 (+)
CBA/J MGP_CBAJ_G0016027
protein coding gene Chr1:96161796-96250155 (+)
DBA/2J MGP_DBA2J_G0016130
protein coding gene Chr1:85710344-85814743 (+)
FVB/NJ MGP_FVBNJ_G0016129
protein coding gene Chr1:84723798-84842597 (+)
LP/J MGP_LPJ_G0016201
protein coding gene Chr1:90804938-90948804 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016154
protein coding gene Chr1:99482916-99623207 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016721
protein coding gene Chr1:89082320-89176774 (+)
PWK/PhJ MGP_PWKPhJ_G0015420
protein coding gene Chr1:85108104-85200267 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015203
protein coding gene Chr1:87963423-88050418 (+)
WSB/EiJ MGP_WSBEiJ_G0015694
protein coding gene Chr1:88776058-88867406 (+)



Homology
more
  • Human Ortholog
    TRPM8, transient receptor potential cation channel subfamily M member 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPM8, transient receptor potential cation channel subfamily M member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LTrpC-6, LTRPC6, trp-p8, TRPP8
  • Links
    NCBI Gene ID: 79054
    neXtProt AC: NX_Q7Z2W7
    UniProt: Q7Z2W7

  • Chr Location
    2q37.1; chr2:233917342-234019522 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased sensitivity to cold and reduced response to cold stimuli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 171382 NCBI Gene Model | MGI Sequence Detail 82142 C57BL/6J ±  kb
transcript NM_134252 RefSeq | MGI Sequence Detail 3869 Not Specified  
polypeptide Q8R4D5 UniProt | EBI | MGI Sequence Detail 1104 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001719 transient receptor potential cation channel TRPM8
  • InterPro Domains
    IPR029603 Transient receptor potential cation channel subfamily M member 8
Molecular
Reagents
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  • All nucleic 8
    cDNA 5
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 96
    Developmental Gene Expression 17
    Gene Ontology 13
    Phenotypes 39
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:264045 Beukema P, et al., TrpM8-mediated somatosensation in mouse neocortex. J Comp Neurol. 2018 Jun 15;526(9):1444-1456

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory