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Pfkfb3
Gene Detail
 Symbol
Name
ID
Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
MGI:2181202
Synonyms E330010H22Rik, uPFK-2
Feature Type protein coding gene
Genetic Map
Chromosome 2
8.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:11471430-11502101 bp, - strand
From VEGA annotation of GRCm38

  30672 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88708  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 2-phosphatase
Gene Tree: Pfkfb3

Human
homologs
Human Homolog PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
NCBI Gene ID 5209
neXtProt AC  NX_Q16875
Human Synonyms  IPFK2, PFK2
Human Chr (Location)  10p15.1; chr10:6144880-6235545 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality before E8
 
Interactions
Pfkfb3 interacts with 317 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process fructose 2,6-bisphosphate metabolic process, phosphorylation
Component nucleus
Function 6-phosphofructo-2-kinase activity, fructose-2,6-bisphosphate 2-phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (210)    Tissues (115)    Images (31)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 210
cDNA source data(100)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(101) cDNA(100) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000011314 (Evidence)
Ensembl Gene ModelENSMUSG00000026773 (Evidence)
Entrez Gene170768 (Evidence)
UniGene19669
DFCITC1585525, TC1598164, TC1603116, TC1608976
DoTSDT.101398239, DT.101398240, DT.101736903, DT.50315459, DT.55159787, DT.94216704, DT.94216718, DT.99863995
NIA Mouse Gene IndexU022287
EC2.7.1.105, 3.1.3.46
Consensus CDS ProjectCCDS15683.1, CCDS50498.1, CCDS50499.1, CCDS50500.1, CCDS50501.1
International Mouse Knockout Project StatusPfkfb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011314 VEGA Gene Model | MGI Sequence Detail 30672 C57BL/6J ±  kb
transcript OTTMUST00000026511 VEGA | MGI Sequence Detail 2107 Not Applicable 
polypeptide OTTMUSP00000012131 VEGA | MGI Sequence Detail 542 Not Applicable 

For the selected sequences
All sequences(118) RefSeq(25) UniProt(14)
Polymorphisms SNPs within 2kb(380 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013079 6-phosphofructo-2-kinase
InterPro IPR016260 Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase
InterPro IPR003094 Fructose-2,6-bisphosphatase
InterPro IPR013078 Histidine phosphatase superfamily, clade-1
InterPro IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000012580 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Other
accession IDs
MGI:2442800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory