Tg(Myh6-Pfkfb3)7Pne
Transgene Detail

Summary

• Symbol: Tg(Myh6-Pfkfb3)7Pne
• Name: transgene insertion 7, Paul N Epstein
• MGI ID: MGI:3640602
• Synonyms: Mb7
• Transgene: Tg(Myh6-Pfkfb3)7Pne Location: unknown
• Alliance: Tg(Myh6-Pfkfb3)7Pne page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Pfkfb3)7Pne expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pfkfb3 (MGI:2181202)

• Mutation details: This transgene consists of a kinase dead form of Pfkfb3 under the cardiac specific alpha-mysoin heavy chain promoter. Hearts have only 40% as much fructose 2,6-biphosphate as wild-type. (J:94475)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:94475 Donthi RV, et al., Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity. J Biol Chem. 2004 Nov 12;279(46):48085-90
• All: 3 reference(s)