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Rac3 Gene Detail
Summary
  • Symbol
    Rac3
  • Name
    RAS-related C3 botulinum substrate 3
  • Synonyms
    Rac1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180784
    NCBI Gene: 170758
  • Gene Overview
    MyGene.info: RAC3
Location & Maps
more
  • Sequence Map
    Chr11:120721470-120723969 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2500 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.46 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RAC3, ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAC3, ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 5881
    neXtProt AC: NX_P60763

  • Chr Location
    17q25.3; chr17:82031656-82034204 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased stride length and impaired thermal nociception, but have improved motor learning and retention of motor behaviors and normal brain morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004093 VEGA Gene Model | MGI Sequence Detail 2500 C57BL/6J ±  kb
transcript OTTMUST00000009207 VEGA | MGI Sequence Detail 1076 Not Applicable  
polypeptide OTTMUSP00000004488 VEGA | MGI Sequence Detail 192 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    10 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013662 ras-related C3 botulinum toxin substrate 3
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 24
    cDNA 24

    Microarray probesets 2
References
more
  • Summaries
    All 44
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:89658 Bolis A, et al., Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation. Eur J Neurosci. 2003 Nov;18(9):2417-24
  • Latest
    J:222575 Ciuculescu MF, et al., Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo. Blood. 2015 May 14;125(20):3105-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory