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Rac3 Gene Detail
Summary
  • Symbol
    Rac3
  • Name
    Rac family small GTPase 3
  • Synonyms
    Rac1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180784
    NCBI Gene: 170758
  • Gene Overview
    MyGene.info: RAC3
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120721470-120723969 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180784
protein coding gene Chr11:120721468-120723969 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019524
protein coding gene Chr11:125206378-125208877 (+)
A/J MGP_AJ_G0019492
protein coding gene Chr11:119631783-119634282 (+)
AKR/J MGP_AKRJ_G0019462
protein coding gene Chr11:123249010-123251509 (+)
BALB/cJ MGP_BALBcJ_G0019467
protein coding gene Chr11:119991340-119993839 (+)
C3H/HeJ MGP_C3HHeJ_G0019273
protein coding gene Chr11:123572842-123575341 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019915
protein coding gene Chr11:128992179-128994678 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017541
protein coding gene Chr11:116622336-116624901 (+)
CAST/EiJ MGP_CASTEiJ_G0018827
protein coding gene Chr11:125078328-125081357 (+)
CBA/J MGP_CBAJ_G0019244
protein coding gene Chr11:134028169-134030668 (+)
DBA/2J MGP_DBA2J_G0019356
protein coding gene Chr11:118999846-119002345 (+)
FVB/NJ MGP_FVBNJ_G0019348
protein coding gene Chr11:118714353-118716852 (+)
LP/J MGP_LPJ_G0019428
protein coding gene Chr11:125507891-125510390 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019381
protein coding gene Chr11:132865475-132867974 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019955
protein coding gene Chr11:123918036-123920535 (+)
PWK/PhJ MGP_PWKPhJ_G0018593
protein coding gene Chr11:120444647-120447114 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018385
protein coding gene Chr11:123687693-123690192 (+)
WSB/EiJ MGP_WSBEiJ_G0018879
protein coding gene Chr11:123915103-123919253 (+)



Homology
more
  • Human Ortholog
    RAC3, Rac family small GTPase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAC3, Rac family small GTPase 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5881
    neXtProt AC: NX_P60763
    UniProt: P60763

  • Chr Location
    17q25.3; chr17:82031656-82034204 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased stride length and impaired thermal nociception, but have improved motor learning and retention of motor behaviors and normal brain morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018012 Ensembl Gene Model | MGI Sequence Detail 2500 C57BL/6J ±  kb
transcript ENSMUST00000018156 Ensembl | MGI Sequence Detail 1076 Not Applicable  
polypeptide ENSMUSP00000018156 Ensembl | MGI Sequence Detail 192 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 2
References
more
  • Summaries
    All 53
    Developmental Gene Expression 8
    Gene Ontology 10
    Phenotypes 17
  • Earliest
    J:89658 Bolis A, et al., Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation. Eur J Neurosci. 2003 Nov;18(9):2417-24
  • Latest
    J:250951 Donnelly SK, et al., Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. J Cell Biol. 2017 Dec 4;216(12):4331-4349

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory