Mchr1
Gene Detail

Symbol Name ID

Mchr1 melanin-concentrating hormone receptor 1 MGI:2180756

Synonyms

Gpr24, Gpr24-9, Mch1r, MCH-1R, melanin-concentrating hormone receptor 1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

38.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:81235499-81238963 bp, + strand From Ensembl annotation of GRCm38   3465 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: melanin-concentrating hormone receptor 1
Gene Tree: Mchr1

Human homologs

Human Homolog		MCHR1, melanin-concentrating hormone receptor 1
NCBI Gene ID		2847
neXtProt AC		NX_Q99705
Human Synonyms		GPR24, MCH1R, MCH-1R, SLC1, SLC-1
Human Chr (Location)		22q13.2; chr22:41075182-41078818 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(11)
 

Homozygous mice for some alleles may display osteoporosis, resistance to diet-induced obesity, abnormal pyramidal neuron physiology, hyperactivity, polyphagia, increased heart rate and body temperature, sleep behavior, and impaired conditioned learning.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell surface receptor signaling pathway, elevation of cytosolic calcium ion concentration, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, hormone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 26

Assay Type	Results
RT-PCR	2

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(5) Primer pair(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000050164 (Evidence)
Entrez Gene	207911 (Evidence)
UniGene	323523
DFCI	TC1661446, TC1682493
DoTS	DT.91309677
Consensus CDS Project	CCDS49675.1
International Mouse Knockout Project Status	Mchr1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000050164	Ensembl Gene Model | MGI Sequence Detail	3465	C57BL/6J
transcript	ENSMUST00000166855	Ensembl | MGI Sequence Detail	2188	Not Applicable
polypeptide	ENSMUSP00000126191	Ensembl | MGI Sequence Detail	353	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

SNPs within 2kb(67 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR004047	Melanin-concentrating hormone 1 receptor
InterPro	IPR008361	Melanin-concentrating hormone receptor
Protein Ontology	PR:000001144	melanin-concentrating hormone receptor 1

References

(Earliest) J:70827 Ehringer MA, et al., High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63
(Latest) J:194588 Chee MJ, et al., Neurochemical charaterization of neurons expressing melanin-concentrating hormone receptor 1 in the mouse hypothalamus. J Comp Neurol. 2013;
All references(55)

Other accession IDs

MGI:2146183