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Tnfsf15
Gene Detail
 Symbol
Name
ID
Tnfsf15
tumor necrosis factor (ligand) superfamily, member 15
MGI:2180140
Synonyms TL1, TL1A, VEGI
Feature Type protein coding gene
Genetic Map
Chromosome 4
34.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:63727084-63745113 bp, - strand
From VEGA annotation of GRCm38

  18030 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Tnfsf15

Human
homologs
Human Homolog TNFSF15, tumor necrosis factor (ligand) superfamily, member 15
NCBI Gene ID 9966
neXtProt AC  NX_O95150
Human Synonyms  TL1, TL1A, VEGI, VEGI192A
Human Chr (Location)  9q32; chr9:114784635-114806128 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants display decreased clinical severity in experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of NF-kappaB-inducing kinase activity, ...
Component extracellular region, extracellular space, ...
Function cytokine activity, death receptor binding, ...
External Resources: FuncBase
Expression
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(6) Genomic(1) cDNA(5)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000000303 (Evidence)
Ensembl Gene ModelENSMUSG00000050395 (Evidence)
Entrez Gene326623 (Evidence)
UniGene208152
DFCITC1589708, TC1635802
DoTSDT.101344981
NIA Mouse Gene IndexU025157
Consensus CDS ProjectCCDS18263.2
International Mouse Knockout Project StatusTnfsf15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000303 VEGA Gene Model | MGI Sequence Detail 18030 C57BL/6J ±  kb
transcript OTTMUST00000000776 VEGA | MGI Sequence Detail 3347 Not Applicable 
polypeptide OTTMUSP00000000344 VEGA | MGI Sequence Detail 270 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(225 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008064 Fas ligand
InterPro IPR006052 Tumour necrosis factor
InterPro IPR006053 Tumour necrosis factor alpha/beta/c
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000002223 tumor necrosis factor ligand superfamily member 15
References (Earliest) J:75557 Migone TS, et al., TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 2002 Mar;16(3):479-92
(Latest) J:207029 Wang X, et al., TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses. J Immunol. 2013 Dec 1;191(11):5420-9
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory