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Tnfsf15
Gene Detail
Symbol

Name
ID
Tnfsf15
tumor necrosis factor (ligand) superfamily, member 15
MGI:2180140
Synonyms
TL1, TL1A, VEGI
Feature Type
protein coding gene
Genetic Map
Chromosome 4
34.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:63727084-63745113 bp, - strand
From VEGA annotation of GRCm38

  18030 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TNFSF15
Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Tnfsf15

Human
homologs
TNFSF15, tumor necrosis factor (ligand) superfamily, member 15
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9966
neXtProt AC: NX_O95150

Human Synonyms: TL1, TL1A, VEGI, VEGI192A

Human Chr (Location): 9q32; chr9:114784635-114806128 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(4) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants display decreased clinical severity in experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis.
 
Human Diseases Modeled in Mice Using Tnfsf15 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Tnfsf15 interacts with 298 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) Genomic(1) cDNA(5)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000000303 (Evidence)
Ensembl Gene Model ENSMUSG00000050395 (Evidence)
Entrez Gene 326623 (Evidence)
UniGene 208152
DFCI TC1589708, TC1635802
DoTS DT.101344981
NIA Mouse Gene Index U025157
Consensus CDS Project CCDS18263.2
International Mouse Phenotyping Consortium Status Tnfsf15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000303 VEGA Gene Model | MGI Sequence Detail 18030 C57BL/6J ±  kb
transcript OTTMUST00000000776 VEGA | MGI Sequence Detail 3347 Not Applicable 
polypeptide OTTMUSP00000000344 VEGA | MGI Sequence Detail 270 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(225 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008064 Fas ligand
InterPro IPR006052 Tumour necrosis factor
InterPro IPR006053 Tumour necrosis factor alpha/beta/c
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000002223 tumor necrosis factor ligand superfamily member 15
References
(Earliest) J:75557 Migone TS, et al., TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 2002 Mar;16(3):479-92
(Latest) J:207029 Wang X, et al., TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses. J Immunol. 2013 Dec 1;191(11):5420-9
All references(29)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory