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Adamts14 Gene Detail
Summary
  • Symbol
    Adamts14
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 14
  • Synonyms
    Adamts-14, TS14
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179942
    NCBI Gene: 237360
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61032891-61109217 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.16 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179942
protein coding gene Chr10:61032886-61109447 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017276
protein coding gene Chr10:60510413-60595824 (-)
A/J MGP_AJ_G0017254
protein coding gene Chr10:58711010-58787842 (-)
AKR/J MGP_AKRJ_G0017214
protein coding gene Chr10:60243470-60321923 (-)
BALB/cJ MGP_BALBcJ_G0017214
protein coding gene Chr10:58784767-58863534 (-)
C3H/HeJ MGP_C3HHeJ_G0017037
protein coding gene Chr10:60143673-60224986 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017672
protein coding gene Chr10:62647294-62744852 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015363
protein coding gene Chr10:55689268-55768955 (-)
CAST/EiJ MGP_CASTEiJ_G0016608
protein coding gene Chr10:60126369-60208235 (-)
CBA/J MGP_CBAJ_G0017009
protein coding gene Chr10:64984712-65091903 (-)
DBA/2J MGP_DBA2J_G0017114
protein coding gene Chr10:57983803-58061823 (-)
FVB/NJ MGP_FVBNJ_G0017108
protein coding gene Chr10:57239763-57317642 (-)
LP/J MGP_LPJ_G0017189
protein coding gene Chr10:60911970-61000056 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017136
protein coding gene Chr10:67348885-67438152 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017710
protein coding gene Chr10:60051720-60137397 (-)
PWK/PhJ MGP_PWKPhJ_G0016391
protein coding gene Chr10:57812314-57892779 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016174
protein coding gene Chr10:59401566-59480224 (-)
WSB/EiJ MGP_WSBEiJ_G0016672
protein coding gene Chr10:59976116-60060636 (-)



Homology
more
  • Human Ortholog
    ADAMTS14, ADAM metallopeptidase with thrombospondin type 1 motif 14
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS14, ADAM metallopeptidase with thrombospondin type 1 motif 14
  • Links
    NCBI Gene ID: 140766
    neXtProt AC: NX_Q8WXS8
    UniProt: Q8WXS8

  • Chr Location
    10q22.1; chr10:70672506-70762441 (+)  GRCh38

Human Diseases
more
  • Diseases
    3 with human ADAMTS14 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    24 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, healthy and fertile and exhibit normal aminoprocollagen processing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059901 Ensembl Gene Model | MGI Sequence Detail 76327 C57BL/6J ±  kb
    transcript ENSMUST00000120336 Ensembl | MGI Sequence Detail 3645 Not Applicable  
    polypeptide ENSMUSP00000112723 Ensembl | MGI Sequence Detail 1209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR013273 ADAMTS/ADAMTS-like
      IPR045371 ADAMTS/ADAMTS-like, cysteine-rich domain 3
      IPR010294 ADAMTS/ADAMTS-like, Spacer 1
      IPR041645 ADAMTS, cysteine-rich domain 2
      IPR024079 Metallopeptidase, catalytic domain superfamily
      IPR001590 Peptidase M12B, ADAM/reprolysin
      IPR002870 Peptidase M12B, propeptide
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:338595 Kentistou KA, et al., Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene. Nat Commun. 2023 Jan 19;14(1):307

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory