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Pla2g16 Gene Detail
Summary
  • Symbol
    Pla2g16
  • Name
    phospholipase A2, group XVI
  • Synonyms
    Hrasls3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179715
    NCBI Gene: 225845
  • Gene Overview
    MyGene.info: PLA2G16
Location & Maps
more
  • Sequence Map
    Chr19:7557459-7588545 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31087 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.33 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PLA2G16, phospholipase A2 group XVI
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PLA2G16, phospholipase A2 group XVI
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AdPLA, HRASLS3, HREV107, H-REV107, H-REV107-1, HREV107-1, HREV107-3, HRSL3
  • Links
    NCBI Gene ID: 11145
    neXtProt AC: NX_P53816
    UniProt: P53816

  • Chr Location
    11q12.3-q13.1; chr11:63574462-63616926 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased lipolysis, decreased susceptibility to diet- or leptin deficiency-induced obesity, hepatic steatosis and altered glucose homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033094 VEGA Gene Model | MGI Sequence Detail 31087 C57BL/6J ±  kb
transcript OTTMUST00000082691 VEGA | MGI Sequence Detail 3048 Not Applicable  
polypeptide OTTMUSP00000044358 VEGA | MGI Sequence Detail 168 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    224 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 28
    cDNA 28

    Microarray probesets 3
Other
Accession IDs
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MGI:2147787
References
more
  • Summaries
    All 35
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:185104 Uyama T, et al., Regulation of peroxisomal lipid metabolism by catalytic activity of tumor suppressor H-rev107. J Biol Chem. 2012 Jan 20;287(4):2706-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory