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Pla2g16 Gene Detail
Summary
  • Symbol
    Pla2g16
  • Name
    phospholipase A2, group XVI
  • Synonyms
    Hrasls3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179715
    NCBI Gene: 225845
  • Gene Overview
    MyGene.info: PLA2G16
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:7557459-7588545 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179715
protein coding gene Chr19:7557433-7588545 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024794
protein coding gene Chr19:4704739-4737845 (+)
A/J MGP_AJ_G0024761
protein coding gene Chr19:4352331-4384017 (+)
AKR/J MGP_AKRJ_G0024734
protein coding gene Chr19:4473974-4505871 (+)
BALB/cJ MGP_BALBcJ_G0024761
protein coding gene Chr19:4450670-4483865 (+)
C3H/HeJ MGP_C3HHeJ_G0024528
protein coding gene Chr19:4609238-4640933 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025207
protein coding gene Chr19:4805495-4835584 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022641
protein coding gene Chr19:4243204-4274546 (+)
CAST/EiJ MGP_CASTEiJ_G0024001
protein coding gene Chr19:4522998-4554427 (+)
CBA/J MGP_CBAJ_G0024501
protein coding gene Chr19:4869530-4901092 (+)
DBA/2J MGP_DBA2J_G0024628
protein coding gene Chr19:4300379-4331640 (+)
FVB/NJ MGP_FVBNJ_G0024593
protein coding gene Chr19:4342806-4374018 (+)
LP/J MGP_LPJ_G0024714
protein coding gene Chr19:4553926-4585330 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024623
protein coding gene Chr19:4769980-4805198 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025255
protein coding gene Chr19:4643600-4675201 (+)
PWK/PhJ MGP_PWKPhJ_G0023747
protein coding gene Chr19:4366757-4398482 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023551
protein coding gene Chr19:4438132-4469611 (+)
WSB/EiJ MGP_WSBEiJ_G0024063
protein coding gene Chr19:4534465-4565208 (+)



Homology
more
  • Human Ortholog
    PLA2G16, phospholipase A2 group XVI
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PLA2G16, phospholipase A2 group XVI
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AdPLA, HRASLS3, HREV107, H-REV107, H-REV107-1, HREV107-1, HREV107-3, HRSL3
  • Links
    NCBI Gene ID: 11145
    neXtProt AC: NX_P53816
    UniProt: P53816

  • Chr Location
    11q12.3-q13.1; chr11:63574462-63616926 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased lipolysis, decreased susceptibility to diet- or leptin deficiency-induced obesity, hepatic steatosis and altered glucose homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060675 Ensembl Gene Model | MGI Sequence Detail 31087 C57BL/6J ±  kb
transcript ENSMUST00000136465 Ensembl | MGI Sequence Detail 3048 Not Applicable  
polypeptide ENSMUSP00000119403 Ensembl | MGI Sequence Detail 168 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    cDNA 29

    Microarray probesets 3
Other
Accession IDs
less
MGI:2147787
References
more
  • Summaries
    All 39
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:244476 Staring J, et al., PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature. 2017 Jan 19;541(7637):412-416

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory