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Pfn3 Gene Detail
Summary
  • Symbol
    Pfn3
  • Name
    profilin 3
  • Synonyms
    1700012P12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178800
    NCBI Gene: 75477
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:55414688-55415232 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.06 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178800
protein coding gene Chr13:55414688-55415232 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020595
protein coding gene Chr13:54894353-54894766 (-)
A/J MGP_AJ_G0020549
protein coding gene Chr13:52865216-52865629 (-)
AKR/J MGP_AKRJ_G0020527
protein coding gene Chr13:54419506-54419919 (-)
BALB/cJ MGP_BALBcJ_G0020545
protein coding gene Chr13:53092627-53093040 (-)
C3H/HeJ MGP_C3HHeJ_G0020344
protein coding gene Chr13:54236082-54236495 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020979
protein coding gene Chr13:56546732-56547145 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018561
protein coding gene Chr13:50812866-50813279 (-)
CAST/EiJ MGP_CASTEiJ_G0019858
protein coding gene Chr13:54336530-54336943 (-)
CBA/J MGP_CBAJ_G0020304
protein coding gene Chr13:58715313-58715726 (-)
DBA/2J MGP_DBA2J_G0020427
protein coding gene Chr13:52416895-52417308 (-)
FVB/NJ MGP_FVBNJ_G0020406
protein coding gene Chr13:51885277-51885690 (-)
LP/J MGP_LPJ_G0020503
protein coding gene Chr13:55150151-55150564 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020435
protein coding gene Chr13:58185345-58185758 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021022
protein coding gene Chr13:54011020-54011433 (-)
PWK/PhJ MGP_PWKPhJ_G0019614
protein coding gene Chr13:52442951-52443364 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019441
protein coding gene Chr13:52931379-52931792 (-)
WSB/EiJ MGP_WSBEiJ_G0019920
protein coding gene Chr13:54367792-54368205 (-)



Homology
more
  • Human Ortholog
    PFN3, profilin 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PFN3, profilin 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 345456
    neXtProt AC: NX_P60673
    UniProt: P60673

  • Chr Location
    5q35.3; chr5:177400107-177400636 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Pfn3
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 75477 NCBI Gene Model | MGI Sequence Detail 545 C57BL/6J ±  kb
transcript NM_029303 RefSeq | MGI Sequence Detail 574 Not Specified  
polypeptide Q9DAD6 UniProt | EBI | MGI Sequence Detail 137 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
Other
Accession IDs
less
MGI:1922727
References
more
  • Summaries
    All 27
    Diseases 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:190741 Migdalska AM, et al., Generation of the Sotos syndrome deletion in mice. Mamm Genome. 2012 Dec;23(11-12):749-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory