About   Help   FAQ
Cys1
Gene Detail
 Symbol
Name
ID
Cys1
cystin 1
MGI:2177632
Synonyms 2900006B19Rik, ck
Feature Type protein coding gene
Genetic Map
Chromosome 12
8.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr12:24665838-24681813 bp, - strand
From VEGA annotation of GRCm38

  15976 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84604  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Gene Tree: Cys1

Human
homologs
Human Homolog CYS1, cystin 1
NCBI Gene ID 192668
neXtProt AC  NX_Q717R9
Human Chr (Location)  2p25.1; chr2:10056799-10080411 (-)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Spontaneous(1) Targeted(1)
 
Homozygous mutant mice display kidneys cysts, enlarged kidneys that distend the abdomen, increased blood urea nitrogen, and die shortly before or soon after weaning. On some strain backgrounds pancreatic and hepatic cysts and fibrosis are also seen.
 
Human Diseases Modeled Using Mouse Cys1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process inner ear development, kidney development
Component axoneme, cell projection, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (18)    Tissues (13)    Images (3)
Theiler Stages: 23, 26, 28
Assay TypeResults
Northern blot 16
RT-PCR 2
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) Genomic(2) cDNA(18) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000027562 (Evidence)
Ensembl Gene ModelENSMUSG00000062563 (Evidence)
Entrez Gene12879 (Evidence)
UniGene52265
DFCITC1582301, TC1629233, TC1667481
DoTSDT.101366139, DT.489750, DT.97363747
NIA Mouse Gene IndexU033844
Consensus CDS ProjectCCDS36422.1
International Mouse Knockout Project StatusCys1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027562 VEGA Gene Model | MGI Sequence Detail 15976 C57BL/6J ±  kb
transcript OTTMUST00000068253 VEGA | MGI Sequence Detail 1856 Not Applicable 
polypeptide OTTMUSP00000034461 VEGA | MGI Sequence Detail 145 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(271 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000006152 cystin-1
References (Earliest) J:31977 Thomas PE, et al., The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J. Biochem Genet. 1972 Apr;6(2):157-68
(Latest) J:183683 Hulea L, et al., CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases. Gene. 2012 Apr 10;497(1):18-26
All references(83)
Other
accession IDs
MGD-MRK-1987, MGD-MRK-2111, MGI:1920108, MGI:2144986, MGI:88482

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory