Cys1
Gene Detail

Symbol Name ID

Cys1 cystin 1 MGI:2177632

Synonyms

2900006B19Rik, ck

Feature Type

protein coding gene

Genetic Map

Chromosome 12

8.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr12:24665838-24681813 bp, - strand From VEGA annotation of GRCm38   15976 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:84604  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Gene Tree: Cys1

Human homologs

Human Homolog		CYS1, cystin 1
NCBI Gene ID		192668
neXtProt AC		NX_Q717R9
Human Chr (Location)		2p25.1; chr2:10196926-10220538 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(1) Spontaneous(1)
 

Homozygous mutant mice display kidneys cysts, enlarged kidneys that distend the abdomen, increased blood urea nitrogen, and die shortly before or soon after weaning. On some strain backgrounds pancreatic and hepatic cysts and fibrosis are also seen.

 
Human Diseases Modeled Using Mouse Cys1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	inner ear development, kidney development
Component	cell projection, cilium, ...
Function	molecular_function

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (18)    Tissues (13)    Images (3)
Theiler Stages: 23, 26, 28

Assay Type	Results
Northern blot	16
RT-PCR	2

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(2) cDNA(18) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000027562 (Evidence)
Ensembl Gene Model	ENSMUSG00000062563 (Evidence)
Entrez Gene	12879 (Evidence)
UniGene	52265
DFCI	TC1582301, TC1629233, TC1667481
DoTS	DT.101366139, DT.489750, DT.97363747
NIA Mouse Gene Index	U033844
Consensus CDS Project	CCDS36422.1
International Mouse Knockout Project Status	Cys1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027562	VEGA Gene Model | MGI Sequence Detail	15976	C57BL/6J
transcript	OTTMUST00000068253	VEGA | MGI Sequence Detail	1856	Not Applicable
polypeptide	OTTMUSP00000034461	VEGA | MGI Sequence Detail	145	Not Applicable

All sequences(58) RefSeq(6) UniProt(2)

Polymorphisms

SNPs(53 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000006152	cystin-1

References

(Earliest) J:31977 Thomas PE, et al., The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J. Biochem Genet. 1972 Apr;6(2):157-68
(Latest) J:183683 Hulea L, et al., CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases. Gene. 2012 Apr 10;497(1):18-26
All references(82)

Other accession IDs

MGD-MRK-1987, MGD-MRK-2111, MGI:1920108, MGI:2144986, MGI:88482