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Helq Gene Detail
Summary
  • Symbol
    Helq
  • Name
    helicase, POLQ-like
  • Synonyms
    D430018E21Rik, Hel308
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176740
    NCBI Gene: 191578
Location & Maps
more
  • Sequence Map
    Chr5:100762145-100798598 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36454 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 48.52 cM, cytoband E
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HELQ, helicase, POLQ-like
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HELQ, helicase, POLQ-like
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HEL308
  • Links
    NCBI Gene ID: 113510
    neXtProt AC: NX_Q8TDG4

  • Chr Location
    4q21.23; chr4:83407343-83455883 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 14667
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: HELQ
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Genomic Mutations
    3 involving Helq
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced fertility and increased incident of tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026173 VEGA Gene Model | MGI Sequence Detail 36454 C57BL/6J ±  kb
transcript OTTMUST00000064661 VEGA | MGI Sequence Detail 3689 Not Applicable  
polypeptide OTTMUSP00000032142 VEGA | MGI Sequence Detail 1069 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    290 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008507 ATP-dependent DNA helicase HEL308
  • EC
  • InterPro Domains
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 52
    cDNA 52

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141056, MGI:2443481
References
more
  • Summaries
    All 28
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:211173 Luebben SW, et al., Helq acts in parallel to Fancc to suppress replication-associated genome instability. Nucleic Acids Res. 2013 Dec;41(22):10283-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory