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Helq Gene Detail
Summary
  • Symbol
    Helq
  • Name
    helicase, POLQ-like
  • Synonyms
    D430018E21Rik, Hel308
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176740
    NCBI Gene: 191578
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:100762145-100798598 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 48.52 cM, cytoband E
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2176740
protein coding gene Chr5:100762144-100798663 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029791
protein coding gene Chr5:102272512-102309954 (-)
A/J MGP_AJ_G0029757
protein coding gene Chr5:98458689-98495898 (-)
AKR/J MGP_AKRJ_G0029703
protein coding gene Chr5:101698053-101734532 (-)
BALB/cJ MGP_BALBcJ_G0029767
protein coding gene Chr5:99484871-99521341 (-)
C3H/HeJ MGP_C3HHeJ_G0029490
protein coding gene Chr5:102045668-102083386 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030222
protein coding gene Chr5:106519642-106557232 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027457
protein coding gene Chr5:93699431-93738681 (-)
CAST/EiJ MGP_CASTEiJ_G0028901
protein coding gene Chr5:100711321-100748885 (-)
CBA/J MGP_CBAJ_G0029460
protein coding gene Chr5:110216056-110254795 (-)
DBA/2J MGP_DBA2J_G0029604
protein coding gene Chr5:98647589-98684756 (-)
FVB/NJ MGP_FVBNJ_G0029563
protein coding gene Chr5:97450832-97487344 (-)
LP/J MGP_LPJ_G0029692
protein coding gene Chr5:102885464-102921900 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029592
protein coding gene Chr5:115276091-115313469 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030255
protein coding gene Chr5:101180790-101217823 (-)
PWK/PhJ MGP_PWKPhJ_G0028619
protein coding gene Chr5:97083746-97120252 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028454
protein coding gene Chr5:98853146-98889616 (-)
WSB/EiJ MGP_WSBEiJ_G0028979
protein coding gene Chr5:101516131-101553689 (-)



Homology
more
  • Human Ortholog
    HELQ, helicase, POLQ like
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HELQ, helicase, POLQ like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL308
  • Links
    NCBI Gene ID: 113510
    neXtProt AC: NX_Q8TDG4
    UniProt: Q8TDG4

  • Chr Location
    4q21.23; chr4:83407343-83455883 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 14667
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HELQ
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced fertility and increased incident of tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035266 Ensembl Gene Model | MGI Sequence Detail 36454 C57BL/6J ±  kb
transcript ENSMUST00000044684 Ensembl | MGI Sequence Detail 3689 Not Applicable  
polypeptide ENSMUSP00000041599 Ensembl | MGI Sequence Detail 1069 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 53

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141056, MGI:2443481
References
more
  • Summaries
    All 34
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:211173 Luebben SW, et al., Helq acts in parallel to Fancc to suppress replication-associated genome instability. Nucleic Acids Res. 2013 Dec;41(22):10283-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory