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Ucn2 Gene Detail
Summary
  • Symbol
    Ucn2
  • Name
    urocortin 2
  • Synonyms
    Ucn-2, Urocortin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176375
    NCBI Gene: 171530
  • Gene Overview
    MyGene.info: UCN2
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr9:108986163-108987164 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.63 cM, cytoband F2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2176375
protein coding gene Chr9:108986010-108987164 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035319
protein coding gene Chr9:110933442-110934596 (+)
A/J MGP_AJ_G0035298
protein coding gene Chr9:106865802-106866956 (+)
AKR/J MGP_AKRJ_G0035230
protein coding gene Chr9:109547503-109548657 (+)
BALB/cJ MGP_BALBcJ_G0035292
protein coding gene Chr9:106561303-106562457 (+)
C3H/HeJ MGP_C3HHeJ_G0035002
protein coding gene Chr9:109943895-109945049 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035812
protein coding gene Chr9:113967010-113968164 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032710
protein coding gene Chr9:104271211-104272348 (+)
CAST/EiJ MGP_CASTEiJ_G0034313
protein coding gene Chr9:109918892-109920046 (+)
CBA/J MGP_CBAJ_G0034970
protein coding gene Chr9:117977900-117979054 (+)
DBA/2J MGP_DBA2J_G0035131
protein coding gene Chr9:106316457-106317611 (+)
FVB/NJ MGP_FVBNJ_G0035079
protein coding gene Chr9:105135765-105136919 (+)
LP/J MGP_LPJ_G0035207
protein coding gene Chr9:111124295-111125449 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035118
protein coding gene Chr9:119533380-119534534 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035833
protein coding gene Chr9:109820741-109821895 (+)
PWK/PhJ MGP_PWKPhJ_G0034020
protein coding gene Chr9:106653053-106654206 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033855
protein coding gene Chr9:109890500-109891654 (+)
WSB/EiJ MGP_WSBEiJ_G0034434
protein coding gene Chr9:109720060-109721214 (+)



Homology
more
  • Human Ortholog
    UCN2, urocortin 2
  • Vertebrate Orthologs
    5
  • Human Ortholog
    UCN2, urocortin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SRP, UCNI, UCN-II, UR, URP
  • Links
    NCBI Gene ID: 90226
    neXtProt AC: NX_Q96RP3
    UniProt: Q96RP3

  • Chr Location
    3p21.31; chr3:48561718-48563768 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Female, but not male, mice homozygous for a null allele show a significant increase in the basal daily rhythms of ACTH and corticosterone, altered drinking and feeding responses, and increased antidepressant-like behavior. Mice homozygous for a second null allele show normal social memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 171530 NCBI Gene Model | MGI Sequence Detail 1002 C57BL/6J ±  kb
transcript NM_145077 RefSeq | MGI Sequence Detail 1002 C57BL/6  
polypeptide Q99ML8 UniProt | EBI | MGI Sequence Detail 113 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 1
    cDNA 1

    Microarray probesets 1
References
more
  • Summaries
    All 32
    Gene Ontology 9
    Phenotypes 6
  • Earliest
    J:67860 Reyes TM, et al., Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2843-8
  • Latest
    J:220767 Voltolini C, et al., Urocortin 2 role in placental and myometrial inflammatory mechanisms at parturition. Endocrinology. 2015 Feb;156(2):670-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory